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SDF-1/CXCR4与糖尿病大血管病变关系的研究 被引量:5

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摘要 动脉粥样硬化(atherosclerosis,AS)是糖尿病大血管病变的基本特征,糖尿病AS的特点主要表现为病变血管分布更加广泛,粥样病变更加弥散,管腔狭窄程度更加严重以及斑块更加容易破裂.基质细胞衍生因子-1(stromal cell derived factor 1,SDF-1)是一种趋化因子,能介导血液中的炎症细胞与血管内皮细胞黏附并向血管内膜下迁移,从而发挥生物学作用.有越来越多的研究表明,SDF-1在AS的斑块与血栓形成、内膜的增厚、管腔狭窄等病理过程中起着重要作用,因此SDF-1有望成为治疗AS的新靶点,研究SDF-1/CXCR4对治疗糖尿病大血管病变有着重要意义.…… 作者简介:梁玉娥(1987-),女,广西来宾人,硕士研究生,主要进行糖尿病大血管动脉粥样硬化病变的研究;E-mail:lye2011@163.com.
出处 《现代医药卫生》 2014年第4期528-530,共3页 Journal of Modern Medicine & Health
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