摘要
目的 探讨妊娠6～8周孕妇血清促卵泡生成素（FSH）、黄体生成素（LH）、孕酮（Po）、游离雌三醇（uE3）、游离β-绒毛膜促性腺激素（Fβ-HCG）、睾酮（T）六项激素水平与早孕胚胎发育的关系.方法 采用电化学发光法和时间分辨荧光免疫分析法分别检测早期正常妊娠组106例、非正常妊娠组（先兆流产及胚胎停育、异位妊娠）94例孕妇的血清六项激素水平.结果 正常妊娠组孕妇血清Po、Fβ-HCG、uE3水平较非正常妊娠组显著升高,两组比较差异有统计学意义（P＜0.05）,且三种激素随孕周增加而逐渐升高（P＜0.05）.而孕妇血清FSH、LH、T在早孕期不随妊娠正常与否及孕周的增加而发生明显改变,两组比较差异无统计学意义（P＞0.05）.结论 ①Po、Fβ-HCG任何一项降低,对早孕的维持都有显著影响.②uE3维持在正常参考值范围,对正常妊娠的维持具有协同作用.③FSH、LH、T在妊娠早期维持在低水平,对早期胚胎发育影响和妊娠结局关系不大.
Objective To investigate the correlation between embryonic development and the serum levels of six kinds of hormones,including follicle-stimulating hormone （FSH）,luteinizing hormone （LH）,progesterone （Po）,free estriol （uE3）,free β-human chorionic gonadotropin （Fβ-HCG） and testosterone （T）,which were detected from the women with 6-8 weeks of pregnancy.Methods Serum hormone levels of two groups were detected with electrochemiluminescence and time-resolved fluoroimmunoassay.Normal pregnancy group included 106 cases and abnormal pregnancy group included 94 cases.Results The serum levels of Po,Fβ-HCG and uE3 in normal pregnancy group were significantly higher than those of the abnormal pregnancy group （P ＜ 0.05）,and they also raised gradually with the increase of gestational weeks （P ＜ 0.05）.There was no statistical difference of the two groups in the serum levels of FSH,LH,T and they did not raise with the increase of gestational weeks （P ＞ 0.05）.Conclusion Reduction of the serum levels of Po and Fβ-HCG will influence the maintenance of early pregnancy,while normal serum levels of uE3 will be benefit for it.Low serum levels of FSH,LH and T do not influence the early embryonic development and the pregnant outcome.
出处
《国际医药卫生导报》
2014年第3期378-381,共4页
International Medicine and Health Guidance News
关键词
早期妊娠
六项激素
胚胎发育
Early pregnancy
Six kinds of serum hormone
Embryonic development
