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子宫平滑肌瘤组织中孕激素受体和porin mRNA的表达 被引量：6

Expressions of 3 isoforms of human progesterone receptors and porin mRNA in uterine leiomyoma tissue
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摘要 目的:探讨孕激素促进子宫平滑肌瘤形成的机制。方法:采用RT-PCR方法检测28例子宫平滑肌瘤组织(研究组)和瘤旁正常子宫平滑肌组织(对照组)中新型孕激素受体(PR)-M、PR-A、PR-B和线粒体porin mRNA的表达。结果:研究组PR-M、porin、PR-A和PR-B mRNA的表达均高于对照组(t=23.935、12.881、10.059和9.332,P<0.001);研究组中PR-M和porin mRNA的表达呈正相关(r=0.431,P=0.022)。结论:PR-M可能通过非基因组途径参与子宫平滑肌瘤的形成。 Aim ： To explore the mechanism of progesterone acts on genesis of uterine leiomyoma. Methods： RT-PCR was used to detect the mRNA expressions of progesterone receptor（PR）-M, PR-A, PR-B and porin in 28 cases of uterine leiomyoma（ leiomyoma group, LG） and their corresponding myometrium（ control group, CG）. Results： The mRNA levels of PR-M, porin, PR-A and PR-B were higher in LG compared with those in CG （ t = 23. 935,12.811 , 10. 059 and 9. 332,P 〈 0. 001 ）. Pearson correlation analysis showed that there was positive correlation between PII-M and porin mRNA in LG（ r = 0.431 , P = 0. 022 ）. Conclusion ： PP-M may act through genomie and nongenomic actions in the genesis and growth of uter- ine leiomyoma.
作者 封全灵 刘弘扬
机构地区 郑州大学第三附属医院妇产科
出处 《郑州大学学报（医学版）》 CAS 北大核心 2014年第1期116-119,共4页 Journal of Zhengzhou University(Medical Sciences)
关键词 孕激素受体 子宫平滑肌瘤 PORIN progesterone receptor uterine leiomyoma porin
分类号 R711.74 [医药卫生—妇产科学]
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参考文献10

  • 1Gellersen B,Fernandes MS,Brosens JJ. Non-genomic progesterone actions in female reproduction[J].Hum Re-prod Update,2009,(1):119.
  • 2Dai Q,Shah AA,Garde RV. A Truncated proges-terone receptor (PR-M) localizes to the mitochondrion and controls cellular respiration[J].{H}Molecular Endocrinology,2013,(5):741.
  • 3Behera MA,Dai Q,Garde R. Progesterone stimu-lates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells[J].{H}American Journal of Physiology Endocrinology and Metabolism,2009,(5):E1089.
  • 4Saner KJ,Welter BH,Zhang F. Cloning and expres-sion of a novel,truncated,progesterone receptor[J].{H}Molecular and Cellular Endocrinology,2003,(1/2):155.
  • 5Shoshan-Barmatz V,Israelson A,Brdiczka D. The voltage-dependent anion channel (VDAC):function in intracellular signalling,cell life and cell death[J].{H}Current Pharmaceutical Design,2006,(18):2249.
  • 6Young MJ,Bay DC,Hausner G. The evolutionary history of mitochondrial porins[J].{H}BMC Evolutionary Biology,2007.31.
  • 7Viville B,Charnock-Jones DS,Sharkey AM. Dis-tribution of the A and B forms of the progesterone receptor messenger ribonucleic acid and protein in uterine leiomyo-mata and adjacent myometrium[J].{H}Human Reproduction,1997,(4):815.
  • 8Shoshan-Barmatz V,De Pinto V,Zweckstetter M. VDAC,a multi-functional mitochondrial protein regulating cell life and death[J].{H}Molecular Aspects of Medicine,2010,(3):227.
  • 9Rapizzi E,Pinton P,Szabadkai G. Recombinant ex-pression of the voltage-dependent anion channel enhances the transfer of Ca 2+microdomains to mitochondria[J].{H}Journal of Cell Biology,2002,(4):613.
  • 10Faivre EJ,Lange CA. Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transacti-vation and c-Src-dependent sustained activation of Erk 1/2 mitogen-activated protein kinase in breast cancer cells[J].{H}Molecular and Cellular Biology,2007,(2):466.

同被引文献25

  • 1杨义军,李红伟,杨思福,赵红霞,王勇,王晓轩.子宫动脉栓塞治疗症状性子宫平滑肌瘤22例体会[J].郑州大学学报（医学版）,2006,41(1):185-186. 被引量：1
  • 2王玮,许伟,丁淑玉,周宝森.以人群为基础子宫肌瘤危险因素病例对照研究[J].中华肿瘤防治杂志,2007,14(11):821-823. 被引量：24
  • 3高霭峰,崔秀娟,李丹.子宫绒毛叶状分割性平滑肌瘤3例临床病理分析[J].中国医科大学学报,2007,36(5):598-599. 被引量：5
  • 4Feng Q, Crochet JR, Dai Q, et al. Expression of a mitoehondrial progesterone reeeptor (PR-M) in leiomyomata and association with increased mitoehondrial membrane potential [ J]. J Clin Endocrinol Metab, 2014, 109 (5): 344.
  • 5Ishikawa H, Ishi K, Serna VA, et al. Progesterone is essential for maintenance and growth of uterine leiomyoma [ J]. Endocrinology, 2010, 151 (6): 2433.
  • 6Kim JJ, Sefton EC. The role of progesterone signaling in the patho- genesis of uterine leiomyoma [ J]. Mol Cell Endocrinol, 2012, 358 (2) : 223.
  • 7Rice KE, Secrist JR, Woodrow EL, et al. Etiology, diagnosis, and management of uterine leiomyomas [ J ]. J Midwifery Womens Health, 2012, 57 (3): 241.
  • 8Curti ML, Jacob P, Borges MC, et al. Studies of gene variants relat- ed to infiammtion, oxidative stress, dyslipidemia, and obesity: im- plications for a nutrigenetic approach [J]. J Obes, 2011 : 497.
  • 9Jeng YJ,Kochukow MY, Watson CS. Membrane estrogen receptor-a- mediated nongenomic actions of phytoestrogens in GH3/B6/F10 pitui- tary tumor cells [ J ]. J Mol Signal ,2009,4 (1) :2.
  • 10Huyck KL, Panhuysen CI, Cuenco KT, et al. The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leio- myomata among affected sisters [ J]. Am J Obstet Gynecol, 2008, 198 (2): 168.

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郑州大学学报（医学版）
2014年 第1期

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