摘要
目的探讨胃癌组织中SOX2表达水平及其与胃癌生物学行为的关系。方法采用Elivsion免疫组织化学法检测80例胃癌和60例癌旁组织标本中SOX2蛋白的表达,分析SOX2蛋白表达与胃癌临床生物学行为的关系。结果胃癌和癌旁组织中SOX2蛋白的阳性表达率分别为23.8%和81.7%,胃癌组织中SOX2蛋白的阳性表达率明显低于癌旁组织(P<0.01)。胃癌组织中SOX2蛋白表达与患者TNM分期、分化程度、淋巴结转移以及是否浸润浆膜密切相关(P<0.01),而与患者年龄、性别及肿瘤大小无关(P>0.05)。结论胃癌组织中SOX2的表达出现下调或缺失的表现,SOX2参与了胃癌的发生过程,且其表达与胃癌浸润、转移等恶性生物学行为密切相关。
Objective To study the relationship between the expression of SOX2 in gastric cancer tissues as well as the biological behaviors of gastric cancer. Methods The expression of SOX2 were detected by immunohistochemieal Elivision TM Immunohistochemistry in 80 cases of gastric cancer and 60 cases of carcinoma tissues,further analyzed SOX2 in gastric cancer tissues as well as the biological behaviors of gastric cancer. Results The positive expression rates of SOX2 protein in gastric cancer and carcinoma tissues were 23.8%, 81.7% respectively. The positive expression rates of SOX2 in gastric cancer were significantly lower than that in carcinoma tissues （P〈0.01）. The positive expression rates of SOX2 protein in gastric cancer significantly corelated with TNM staging,differentiation degree, lymph node metastasis, distant metastasis （P〈0.01）. And showed no Correlativity with age, sex and tumor size. Conclusion The low expression of SOX2 protein may play important roles in the carcinogenesis of gastric cancer and it is involved in the metastasis and infihration.
出处
《中国现代医生》
2014年第3期4-5,10,F0003,共4页
China Modern Doctor
基金
浙江省公益技术研究社会发展项目(2010C33118)
