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大麻二酚神经保护作用机制研究进展 被引量：17

Research progress on mechanism of neuroprotective effects of cannabidiol
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摘要 大麻Cannabis sativa是一种古老的具有药用开发利用价值的栽培植物。大麻素是大麻中特有的萜类次生代谢产物,具有复杂的生物活性,目前已分离得到70多种大麻素,其中主要活性成分为四氢大麻酚(THC)和大麻二酚(CBD)。THC与CBD均具有神经保护作用。THC因具有强致幻性其应用受限,CBD无成瘾性且具有抗痉挛、抗风湿关节炎及抗焦虑作用。近年来,CBD的神经保护作用及其机制成为研究热点,对CBD神经保护作用的研究进展进行综述。
作者 殷莎 唐双奇 陆阳
机构地区 上海交通大学医学院
出处 《中草药》 CAS CSCD 北大核心 2014年第3期432-436,共5页 Chinese Traditional and Herbal Drugs
基金 国家自然科学基金资助项目(30873057 81171245) 上海市科委基础重点项目(11JC1406600)
关键词 大麻二酚 大麻素受体 5HT1A受体 腺苷受体 神经保护 cannabidiol cannabinoid receptor 5-HT1A receptor adenosine receptors neuroprotection
分类号 R285 [医药卫生—中药学]
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参考文献22

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  • 2Roser P,Vollenweider F X,Kawohl W. Potential antipsychotic properties of central cannabinoid (CB1) receptor antagonists[J].{H}WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY,2010,(2 Pt 2):208-219.
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二级参考文献42

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共引文献70

同被引文献258

引证文献17

二级引证文献81

中草药
2014年 第3期

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