摘要
目的 探讨复方氨氯地平阿托伐他汀钙片联合黛力新治疗女性更年期高血压的临床疗效.方法 66例更年期女性高血压患者随机分为对照组（复方氨氯地平阿托伐他汀钙片）和治疗组（复方氨氯地平阿托伐他汀钙片联合黛力新）,治疗前、治疗后4周检测两组24 h动态血压,统计总有效率,计算汉密顿焦虑量表（HAMA）评分,进行治疗前后比较和组间比较.结果 ①治疗后4周,与对照组相比,治疗组的24 h SBP、24 h DBP、dSBP及nSBP水平下降更低,差异有统计学意义（均为P＜0.05）;而两组的dDBP及nDBP水平差异无统计学意义.②治疗后4周,对照组的总有效率为75.8%,治疗组的总有效率为93.9%,两组比较差异有统计学意义（x2=4.2429,P=0.0393）.③治疗后4周,治疗组的HAMA评分为13±3,低于对照组的18±4,两组比较差异有统计学意义（t=5.7466,P=0.000）.结论 复方氨氯地平阿托伐他汀钙片联合黛力新治疗更年期女性高血压,可提高整体降压疗效,改善焦虑状态,提高患者的生活质量.
Objective To approach the clinical effect of amlodipine/atorvastatin calcium tablets combine with Deanxit on female climacteric hypertension. Methods 66 female climacteric hypertension patients were divided randomly into control group （amlodipine/atorvastatin calcium tablets） and treatment group （amlodipine/atorvastatin calcium tablets combine with deanxit）. 24 h ambulatory blood pressure monitoring and Hamilton Anxiety score were evaluated in these two groups before and 4 weeks after treatment. Results （1） The 24 h SBP, 24 h DBP, dSBP and nSBP in the treatment groups were lower than the control group 4 weeks after treatment. There was no difference on the dDBP and nDB between two groups. （2） After 4 weeks treatment, the total effective rate in control group was 75.8% and 93.9% in treatment group, which has statistically difference （X2=4.2429, P=-0.0393）. （3）Mter 4 weeks treatment, the Hamilton Anxiety score in treatment group was 13±3 and 18±4 in control group, which has statistically difference （t=5.7466, P=0.000）. Conclusion Amlodipine/atorvastatin calcium tablets combine with deanxit has a clinically effect on female climacteric hypertension.
出处
《中国心血管病研究》
CAS
2014年第1期83-85,共3页
Chinese Journal of Cardiovascular Research
关键词
氨氯地平
阿托伐他汀
黛力新
更年期
高血压
Amlodipine
Atorvastatin
Deanxit
Climacteric period
Hypertension
