摘要
目的探讨CRP在Graves病发展中的影响及临床意义。方法研究对象分Graves病初发组、缓解组、完全缓解组、复发组及正常对照组,检测CRP含量及TSH。结果 CRP正常对照组结果为(0.21±0.14)mg/dl,初发组结果为(0.41±0.52)mg/dl,缓解组结果为(0.18±0.08)mg/dl,完全缓解组结果为(0.31±0.26)mg/dl,复发组结果为(0.19±0.13)mg/dl;初发组结果明显高于正常对照组、缓解组,差异有统计学意义(P分别为0.005、0.011),其余各组别比较虽有差异,但没有统计学意义;CRP与TSH低相关,无统计学意义。结论 CRP在GD中参与免疫反应,对治疗有临床意义,可能为GD病理机制的探讨提供新的线索。
Objective To investigate the effect of CRP in development of Graves disease （GD）. Methods The research objects were divided into untreated GD patients group, remission patients group, complete remission patients group, recurrent pa- tients group and health control group to detect the levels of CRP and TSH. Results CRPlevels in the health control group, untreated GD group, remission GD group, complete remission GD group, and recurrent GD group were （0.21 ±0.14） mg/dl, （0.41 ±0.52） mg/dl, （0. 18±0.08） mg/dl, （0. 31±0. 26） mg/dl, （0. 19 ±0. 13） mg/dl respectively. The CRP level in the untreated GD patients group was apparently higher than that in the health control group and remission patients group, and the differences had statistical significance （P = 0.005, 0.011 ）. While the differences among the other groups had no statistical significance. CRP level was correlated with low TSH, without statistical significance. Conclusion The CRP is involved in the immune response in GD, and it may provide a new clue for pathological mechanism of GD.
出处
《中国卫生检验杂志》
北大核心
2014年第1期72-74,共3页
Chinese Journal of Health Laboratory Technology
基金
湛江市科技攻关项目(2010C3105008)
