摘要
以1,12,15-三氮杂-3,4:9,10-二苯并-5,8-二氧杂环十七烷为原料,合成了含苯并香豆素缀N3O2大环化合物,其结构经1H NMR,MS,元素分析等表征。通过紫外光谱法和荧光光谱法研究表明:目标化合物通过嵌插方式与DNA相互结合。
A N3O2-donor macrocyclic comp ound bearing benzocoumarin group is obtained from 1, 12, 15-triaza-3, 4：9, 10-dibenzo-5, 8-dioxacycloheptadecane, the structure of which is characterized by 1H NMR, MS spectra and elemental analysis. Interactions of the target compound with CT （calf thymus） DNA have been investigated by the ultraviolet spectrophotometry and fluorescence spectrophotometry. The results shows that the binding model is intercalated.
出处
《乐山师范学院学报》
2013年第12期30-32,共3页
Journal of Leshan Normal University
基金
四川省科技厅应用基础项目(2011JYZ006
2009JY0078)
乐山市科技局重点项目(2011SZD107)
关键词
苯并香豆素
N3O2大环
相互作用
小牛胸腺DNA
Benzocoumarin
N3O2-donor Macrocycle
CT DNA
Interaction
