摘要
目的 评价负性生活事件与晚发抑郁障碍的关系.方法 应用循证医学的Meta分析,对负性生活事件与晚发抑郁障碍关系的5项研究进行评价,包括4项病例对照研究,1项队列研究.结果 研究组411例,对照组1 493例.晚发抑郁障碍组与对照组的负性生活事件发生率[OR =2.97,95％ CI （2.27,3.89）,Z=7.95,P＜ 0.000 01]比较均有统计学意义.结论 负性生活事件为晚发抑郁障碍发病的危险因素.
Objective Evaluation of the relationship between negative lite events and late--onset depression disorder. Methods Applied Meta analysis of evidence--based medicine, evaluated five studies about the relationship between negative life events and late--onset depression disorder, including four case--control study, a cohort study. Results 411 cases in the research group, 1493 cases in the control group. The incidence of negative life events between late--onset depression disorder group and the con- trol group were statistically significant [OR： 2.97, 95 %CI （2.27,3.89）,Z= 7.95,P〈0. 000 01]. Conclusions Negative life events are the risk factors for late--onset depression disorder.
出处
《神经疾病与精神卫生》
2013年第6期558-561,共4页
Journal of Neuroscience and Mental Health
