摘要
目的观察双环醇联合多烯磷脂酰胆碱治疗老年非酒精性脂肪性肝病的临床疗效。方法将120例老年非酒精性脂肪性肝病患者采用区组随机化法分为联合组、双环醇组和多烯磷脂酰胆碱组，每组40例。联合组双环醇联合多烯磷脂酰胆碱治疗，双环醇组单纯双环醇治疗，多烯磷脂酰胆碱组单纯多烯磷脂酰胆碱治疗。经过24周治疗后比较三组患者的血液生化指标、肝脏超声积分及临床疗效。结果三组治疗后总胆固醇（TC）、三酰甘油（TG）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、1．谷氨酰转移酶（GGT）均低于治疗前，差异有统计学意义（P〈0．05）；且联合组治疗后TC、TG、ALT均明显低于双环醇组和多烯磷脂酰胆碱组[（1．36±0．84）mmol／L比（2．77±1．27）、（2．84±1．35）mmol／L，（1．32±O．71）mmol/L,比（1．89±0．87）、（1．92±0．90）mmol／L，（38．26±12．75）U／L比（57．834-16．67）、（62．07±18．16）U／L]，差异有统计学意义（P〈0．05）。三组治疗后肝脏超声积分均较治疗前明显下降，差异有统计学意义（P〈0．05）；且联合组治疗后肝脏超声积分明显低于双环醇组和多烯磷脂酰胆碱组[（2．08±0．93）分比（3．17±1．14）、（3．34±1．07）分]，差异有统计学意义（P〈0．05）。联合组总有效率明显高于双环醇组和多烯磷脂酰胆碱组[85．0％（34／40）比67．5％（27，40）、65．0％（26／40）]，差异有统计学意义（P〈0．05）。结论应用双环醇联合多烯磷脂酰胆碱治疗老年非酒精性脂肪性肝病具有良好疗效，优于单用双环醇和多烯磷脂酰胆碱，值得临床推广应用。
Objective To observe the clinical effect of bicyclol combined with polyene phosphatidyl choline in elderly non-alcoholic fatty liver disease （NAFLD）. Methods One hundred and twenty elderly patients with NAFLD were divided into 3 groups by block randomization method,40 cases in each group. Therapeutic group was treated by bicyclol combined with polyene phosphatidyl choline; bicyclol group was only treated by bicyclol; and polyene phosphatidyl choline group was only treated by polyene phosphatidyl choline. The blood biochemical indexes, liver ultrasound score and clinical curative effect of 3 groups were compared after treated for 24 weeks. Results The total cholesterol （TC）,triglyceride （TG）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST） and gamma glutamine transferase （GGT） in 3 groups after treatment were lower than those before treatment, and the difference was statistically significant （P 〈 0.05 ） ; TC, TG and ALT levels in therapeutic group after treatment were significantly lower than those in bicyclol group and polyene phosphatidyl choline group [ （ 1.36± 0.84） mmol/L vs. （2.77 ± 1.27）, （2.84 ±1.35） mmol/L; （1.32 ±0.71） mmol/L vs.（1.89 ±0.87）, （1.92 ±0.90） mmol/L; （38.26 ± 12.75） U/L vs. （57.83 ± 16.67 ）, （62.07 ±18.16 ） U/L ], and the difference was statistically significant （P 〈 0.05 ）. The liver ultrasound score in 3 groups after treatment was significantly decreased compared with that before treatment, and the difference was statistically significant （P 〈 0.05）. Liver ultrasound scores in therapeutic group after treatment were significantly lower than those in bicyclol group and polyene phosphatidyl choline group [ （2.08 ± 0.93 ） scores vs.（3.17 ± 1.14）, （3.34 ± 1.07） scores] ,and the difference was statistically significant （P 〈 0.05 ）. The total effective rate in therapeutic group was significantly higher than that in bicyclol group and polyene phosphatidyl choline group [ 85.0% （34/40） vs. 67.5% （27/40）, 65.0% （26/40） ], and the difference was statistically significant （P 〈0.05）. Conclusions Bicyclol combined with polyene phosphatidyl choline has better clinical effect in elderly patients with NAFLD.It is better than single bicyclol and polyene phosphatidyl choline and worth clinical promotion.
出处
《中国医师进修杂志》
2014年第1期1-3,共3页
Chinese Journal of Postgraduates of Medicine
基金
基金项目：北京市科技新星资助计划（xx2013107）
