摘要
目的 :对尿磷酸二酯酶I监测汞性肾脏损伤进行实验研究。方法 :用微量测定法测定汞作业工人和非职业性汞接触者尿磷酸二酯酶I活性的变化 ,并与尿蛋白和尿肌酐的变化进行比较。结果 :汞作业工人尿汞超标者尿磷酸二酯酶I活性显著升高 ,与对照组比较 ,有非常显著性意义 (P <0 .0 1) ,非职业性汞接触者 (包括皮肤接触和口服者 )尿磷酸二酯酶I活性均显著高于对照组 (P <0 .0 1) ;与Pr、Cr相比较 ,尿磷酸二酯酶I对汞性肾损伤的检测具有更高的敏感性。结论 :尿磷酸二酯酶I是一项能反映汞性肾损伤的敏感指标 ,对于早期诊断汞肾损伤有较高的临床应用价值。
OBJECTIVE:The usuage of uric phosphodiesterase I (PDEI) in detection of Hg harm to kidney was studied.METHODS:With the method of trace detection the activity changes in uric phosphodiesterase I for workers who get tough with Hg professionally and the people who get contact with it occasionally were measuned and compared with the activity changes in Pr and Cr.RESULTS:The activity of uric PDEI in the workers with uric Hg out of normal standard in creased sharply compared with the controls ( P < 0.01 );it is same in the people who eat or tough Hg by skin.Constrasting with Pr and Cr,the activity change in uric PDEI is more sensitive in detecting the Hg harm to kidney.CONCLUSIONS:Uric PDEI is a sensitive index for the Hg harm to kidney,and very useful in its diagnose.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2001年第1期7-8,共2页
Chinese Journal of Hospital Pharmacy
基金
河南省科技攻关基金资助项目 (991170 5 17)
