摘要
目的 :研究充血性心力衰竭 (CHF)患者血清细胞因子的变化及与肾素 -血管紧张素系统的关系。方法 :测定 55例 CHF患者及 2 0例健康人血清肿瘤坏死因子 -α(TNF-α) ,白细胞介素 - 6(IL- 6) ,血浆肾素活性 (PRA) ,血管紧张素 (A ) ;采用心脏超声测定 CHF患者的左室射血分数 (LVEF)。结果 :1血清 TNF-α,IL- 6的水平与 CHF的原发病无关 ,而与心功能状态有关。 2血清 TNF- α,IL- 6水平与 LVEF呈负相关 (r =- 0 .52 ,r=- 0 .64,P <0 .0 5)。3TNF- α与 PRA呈正相关 (r =0 .55,P <0 .0 5)。结论 :细胞因子与肾素
Objective:To study the changes of serum cytokines and relationship between the levels serum cytokines and renin angiotensin system(RAS) in patients with congestive heart failure(CHF).Method:The levels of serum tumour necrosis factor α(TNF α),interleukin 6(IL 6),plasma renin activity(PRA) and angiotensin Ⅱ(A Ⅱ) were determined in 55 cases with CHF and in 20 normal controls.The left ventricular ejective fraction (LVEF) was also measured in those subjets.Result:①The levels of TNF α,IL 6 were related to the cardiac function and were not related to the primary disease of CHF;②There were a negative correlation between the level of TNF α and left ventricular ejection fraction (LVEF) as well as IL 6 and LVEF (r=- 0.52 ,r=- 0.64 ,P< 0.05 );③There was a positive correlation between the level of TNF α and PRA (r= 0.55 ,P< 0.05 ).Conclusion:There were correlation between cytokines and renin angiotensin system.Over activation or interactions of them could deteriorate cardiac function.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2001年第1期26-27,共2页
Journal of Clinical Cardiology
