摘要
目的：探讨漯河市中医院新的／严重的药品不良反应（ADR）的增长趋势，发掘警戒信号，促进临床安全用药。方法：收集我院2010年1月-2012年12月上报至河南省药品不良反应监测中心的91例新的／严重的ADR病例，分别从患者年龄、给药途径、药品种类、累及器官和（或）系统及临床表现、科室分布等方面进行统计、分析。结果：21-60岁患者ADR发生率较高（57例，占62．64％）；静脉滴注给药引发的ADR最多（66例，占72．53％）；中药制剂的ADR报告例数居第1位（29例，31．87％）；ADR的主要临床表现为皮肤及其附件损害（55例次，占总计131例次的41．98％）；新的ADR为87例（占95．60％），严重的ADR为4例（占4．40％），主要出现在内科。结论：要加强引发新的／严重的ADR药物品种的监测工作，重视其信号作用；在使用相关药品时，做到密切巡视观察，及时处理应对，保障患者用药安全。
OBJECTIVE：To explore the increasing tendency of adverse drug reaction （ADR） cases in Henan Luohe Hospital of Traditional Chinese Medicine and explore the warning signal so as to promote clinical safe medication. METHODS： A total of 91 new or serious ADR cases reported by our hospital to Henan ADR monitoring center from Jan. 2010 to Dec. 2012 were analyzed statistically in respect of patients＇ age, route of administration, drug categories, organs or systems involved, clinical manifestation of ADR and its department distribution etc. RESULTS： The ADR occurred more often in patients aged from 21 to 60 years with 57 cases （62. 64% ）, induced mostly by intravenous drip infusion with 66 cases （ accounting for 72.53% ） ; Chinese materia medica-induced ADR cases took the lead in number with 29 cases （31.87%）. The ADR manifested mainly as lesions of skin and its appendants （55 cases, accounting for 41.98% of the total 131 case-times）. There were 87 new ADR cases （95.60%） and 4 cases （4.40%） serious ADR cases, which were predominantly reported from the department of internal medicine. CONCLUSION： It is important to tighten monitoring on the new or serious ADR cases and pay attention to its signalization and give close monitoring when using the related drugs so as to assume timely management in cases of occurrence of ADR and ensure patients＇ medication safety.
出处
《中国医院用药评价与分析》
2013年第12期1111-1113,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
药品不良反应
药物警戒
安全用药
Adverse drug reaction
Pharmacovigilance
Safe medication
