摘要
恶性肿瘤最显著的表型是肿瘤细胞的失控性生长及异常血管增生。传统的手术、放疗及化疗主要是对恶性肿瘤细胞的杀伤和控制,但少有临床治愈。通过抑制血管形成可能治愈肿瘤的假设已日趋完整。近30年的研究表明,无论是生理性还是病理性血管形成,均是由约数十种经典及非经典的正性和负性调节因子共同参与、激活血管形成开关调控的。
Abstract ：The hallmarks of the malignancies are uncontrolled growth of tumor cells and ex c.essive neovascularization. The traditional therapeutic modalities such as operation,radio-therapy and chemotherapy are based on the concept of killing tumor cells. However, rare tu,nors can be cured clinically. The hypothesis of anti-angiogenesis for treating tumor has been systemic and full of findings. The discover7 of angiogenesis studies indicates that a number of classical and non-classical regulators,both positive and negative,form a complex regulation network and participate in the angiogenesis switch process.
出处
《中国肿瘤》
CAS
2014年第1期44-48,共5页
China Cancer
基金
浙江省自然科学基金(LY12H16032)
关键词
恶性肿瘤
血管形成
分子调控
,nalignaney
angiogeuesis
molecular regulator
