摘要
目的 探讨大肠癌中nm2 3 H1的表达与淋巴转移的关系。方法 应用免疫组化方法研究 96例大肠癌中nm2 3 H1蛋白的表达。结果 nm2 3 H1蛋白低表达与淋巴结或远处转移显著相关 (P <0 0 5) ;nm2 3 H1蛋白低表达预测大肠癌转移的灵敏性为 88 4 % ,特异性为 79 3%。结论 检测nm2 3 H1蛋白可以预测大肠癌淋巴结或远处转移 ,从而可能成为临床治疗的判断依据。
To study the relationship between the expression of nm23-H1 and lymph node metastasis in colorectal carcinoma.Methods The expression of nm23-H1 gene product was examined immunohistochemically in resected colorectal carcinomas.Results In tumors with weak immunoreactivity againt nm23-H1,frequency of lymph node metastasis was significantly higher than those with moderate or strong staining( P <0 05).With a sensitivity of 88 4% and specificity of 79 3%,low nm23-H1 immunoreactivity in primary tumor is an indicator of the presence of lymph node metastasis.Conclusion Immunohistochemical evaluation of nm23-H1 in the primary tumor is useful predictor of presence of lymph node metastasis in colorectal carcinomas and may have clinical significance in predicting optional therapetic regimes.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2000年第5期385-386,共2页
Cancer Research on Prevention and Treatment
关键词
大肠癌
NM23-H1
淋巴结转移
预测
Colorectal neoplasms
nm23-H1
Immunohistochemistry
Lymph node metastasis
