摘要
目的:探讨微生态制剂贝飞达对恶性血液病患儿化疗后肠黏膜屏障的保护作用。方法:将60例恶性血液病患儿随机分为对照组和治疗组。分别于化疗后测定两组患儿尿乳果糖与甘露醇的比值(L/M)、血浆二胺氧化酶(DAO)、内毒素(ET)、肿瘤坏死因子(TNF-α)及免疫球蛋白A(IgA)。结果:治疗前两组患儿各项指标差异无统计学意义。治疗后,两组患儿L/M、DAO、ET、TNF-α数值较治疗前升高,IgA数值则较治疗前降低,差异有统计学意义(P<0.05)。治疗组患儿L/M、DAO、ET、TNF-α数值于治疗后明显低于对照组(P<0.05),IgA数值则明显高于对照组(P<0.05),差异均有统计学意义。结论:微生态制剂通过改善肠道菌群状况对恶性血液病化疗后患儿肠黏膜屏障功能具有明显保护作用,对预防化疗引起的肠道细菌内毒素移位具有重要临床意义。
Objective：To investigate the pro-tective effect to intestinal mucosa barrier of microecologics bifido used to treat children with malignant hematopathy chemotherapy. Methods：60 cases of children with malignant hematological disease were randomly divid-ed into treatment group and control group. The two groups were determined index after chemotherapy.The indexes include the ratio of urinary fructose and mannitol（L/M）,plas-ma two amine oxidase（DAO）,endotoxin（ET）, tumor necrosis factor alpha（TNF-α） and immunoglobulin A（IgA）.Results：The differ-ences between the two groups were not sta- tistically significant before treatment.After treatment,it is increased in two groups of L/ M,DAO,ET and TNF- α and IgA values are lower than those before therapy.The differ-ence was statistically significant（P〈0.05）. The treatment group of L/M,DAO,ET and TNF-α was significantly lower than the control group（P〈 0.05） and the IgA value was significantly higher than that of control group （P〈 0.05）.There was significant dif- ference.Conclusion：Micro ecological prepa- ration by improved intestinal flora has obvi- ous protective effects on intestinal mucosal barrier function in children after chemother- apy of malignant blood diseases and it has important clinical significance for preven- tion of intestinal bacteria endotoxin translo- cation induced by chemotherapy.
关键词
双歧杆茵
化疗
肠黏膜屏障
Bacillus bifidus
Chemothera-py
Intestinal mucosal barrier
