摘要
目的:应用D-最优混料设计优化贝母缓释微丸处方。方法:以总生物碱体外释放度为指标,考察浙贝母浸膏、羟丙基甲基纤维素和乙基纤维素用量,通过拟合最佳数学模型,建立三维曲面图预测最优处方范围,并进行验证。结果:所得优化处方范围内,微丸体外释放度的实验值与预测值十分接近,释药曲线接近零级,r=0.9940。结论:优化贝母缓释微丸处方具有明显缓释作用;采用混D-最优料设计-效应面法优化制剂处方,具有准确的预测性。
Objective ： To optimize the matrix formulation of sustained - release pellets of fritillary by D - optimal mixture design. Methods ： The accumulated release of total alkaloids was used as evaluation index to investigate the amount of EC, fritillary extract and HPMC, to fit the best mathematical model and to establish a three - dimensional surface figure for predictive optimal prescription range, and authenticated. Results： In the range of optimizing prescription, the actual test values of pellets in vitro release were very close to predicted values, and the release curve was near zero - order, r = 0. 9940. Conclusion ： The fritillary pellets has sustained - release effect. D - optimal mixture design - response surface methodology optimization can accurately predict the matrix formulation of pharmaceutical preparations.
出处
《中华中医药学刊》
CAS
2014年第2期281-283,I0002,I0003,共5页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81060346)
江西省学位与研究生教育教学改革项目(JXYJG-2012-080)
中国药科大学研究生教育创新计划项目
关键词
贝母
缓释微丸
处方优化
D-最优混料设计
fritillary
sustained - release pellets
optimized formulation
D - optimal mixture design
