摘要
目的探讨T2DM患者血清对氧磷酶3(pon3)水平与血糖、血脂、IR等代谢因素及T2DM早期颈动脉粥样硬化(CAS)的关系。方法选择新诊断T2DM患者108例,根据有无CAS分为合并CAS(A,53例)组和不合并颈动脉斑块(B,55例)组;另选择健康体检者为对照(C,54例)组。采用ELISA方法测定空腹血清pon3水平,检测血脂、同型半胱氨酸(Hcy)、纤维蛋白原(Fib)、HbA1c、FPG、hsC-RP、超氧化物歧化酶(SOD)等指标,采用稳态模型评估胰岛素抵抗指数(HOMA-IR)。结果 3组血清pon3水平依次为:C组(2.24±0.44)ng/ml<B组(2.72±0.51)ng/ml<A组(3.58±0.62)ng/ml(P<0.05或P<0.01);血清pon3水平与BMI、FIns、TC、HOMA-IR、hsC-RP、FPG、HbA1c、Hcy、Fib呈正相关(r分别为0.513、0.523、0.593、0.529、0.517、0.487,0.487、0.547,0.528,P<0.05或P<0.01),与HDL-C、SOD负相关(r=-0.497,-0.589)。多元逐步回归分析显示,BMI、hsC-RP、LDL-C、Fib是影响T2DM患者pon3的独立相关因素。Logistic回归分析显示,BMI、Fib、LDL-C、pon3是T2DM发生CAS的主要影响因素。结论血清pon3在新诊断T2DM合并颈动脉斑块人群中升高,在新诊断T2DM合并CAS的发生中起重要作用。
Objective To explore the association of serum paraoxonase-3 （pon3） with serum glucose, lipid, insulin resistance, and the carotid atherosclerosis （CAS） in the newly diagnosed T2DM patients. Method The 108 patients with newly diagnosed T2DM were divided into T2DM with CAS group （Group A, n=53）, and T2DM without CAS group （Group B, n=55）. The 54 healthy people with normal glucose tolerance were selected as the controls （Group C）. Serum pon3 was measured with the ELISA method. FPG, 2 hPG, FIns, HbA1c, hsC-RP, and lipid profiles, homocysteine （Hcy）, fibrinogen （Fib）, and superoxide dismutase （SOD） were measured as well. BMI and waist-to-hip ratio （WHR） were recorded and insulin sensitivity was assessed by HOMA-IR. Results The serum pon3 levels of the three groups were in an order of Group C （2.24±0.44） 〈 Group B （2.72±0.51） ng/mg/ml〈Group A （3. 584-0. 62）ng/mg/ml （P〈0. 05 or P〈0. 01）. The pon3 level was positively correlated with BMI, Fins, TC, HOMA-IR, hsC-RP, FPG, HbAlc, Hcy, and Fib （r=0. 513, 0. 523, 0. 593, 0. 529, 0. 517, 0. 487, 0.487, 0. 547, 0. 528 respectively （P〈0. 05 or P〈0. 01）, and negatively correlated with HDL-C and SOD （r=-0. 647,-0. 589 ,P〈0. 01）. Multiple stepwise regression analysis showed that BMI, hsC-RP, LDL-C, and Fib were the independent related {actors influencing the plasma pon3 level o{ T2DM patients. Logistic regression analysis showed that BMI, Fib, LDL-C, and the fasting serum pon3 levels were the main factors for macrovascular complications in T2DM Conclusion Serum pon3 is in a higher level and plays a very important role in newly diagnosed T2DM patients accompanied with CAS.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2014年第1期47-50,共4页
Chinese Journal of Diabetes
关键词
对氧磷酶3
糖尿病
2型
颈动脉粥样硬化
Paraoxonase-3 （pon3）
Diabetes mellitus, type 2
Carotid atherosclerosis （CAS）
