摘要
目的:观察丁桂儿脐贴联合用药及丁桂儿口服用药对幼龄大鼠厌食模型的作用。方法:采用病因模拟法制备幼龄大鼠厌食模型,观测大鼠食量、体重、胃酸、胃蛋白酶及血浆CCK-8、β-内啡肽的含量变化。结果:与正常大鼠比较,模型大鼠食量、体重、胃液量均显著降低,血浆CCK-8含量明显增高,提示大鼠食量减退,生长缓慢,且无腹泻等其他症状出现,较符合小儿厌食表现。丁桂儿口服药物(0.8g/kg)及丁桂儿脐贴联合用药(小儿健胃消食片3g/kg或西沙必利片0.6mg/kg联合丁桂儿脐贴)对上述指标有部分调节作用,特别是丁桂儿脐贴大剂量联合西沙必利片可显著降低厌食模型大鼠血浆CCK-8含量,丁桂儿小、大剂量联合健胃消食片,丁桂儿中、大剂量联合西沙必利片均可明显增高厌食模型大鼠血浆β-内啡肽含量。结论:丁桂儿脐贴联合用药对幼龄大鼠厌食模型有一定疗效。
Objective： To observe the effects of Dingguier paste combination with other drugs and Dinggnier oral drugs on the juvenile rat model of anorexia. Methods： Juvenile rat model of anorexia was established by etiology simulation method. Then the food intake, body weight, the contents of hydrochloric acid and pepsin in gastric juice were observed, and the variation of CCK-8 and β-endorphin in plasma were also detected. Results： Compared to normal rats, the food intake, body weight and the volume of gastric juice of the model rats were significantly decreased. And the contents of CCK-8 in plasma increased obviously in model rats. The symptoms of model rats were relatively accordance with infantile anorexia. Dingguier oral drugs and its combinations with other drugs have partly effects on model rats,particularly Dingguier combi- nations with other drugs can decreased the volume of CCK-8 in plasma in the young rats model of anorexia and increased the volume of β-endorphin in plasma. Conclusion： Dingguier combinations with other drugs have some effects on the juvenile rats model of anorexia.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2013年第6期134-137,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
国家重大新药创制项目:丁桂儿脐贴中药大品种技术改造(2011zx09201-201-35)
山西省自然科学基金(2011011035-5)
关键词
丁桂儿脐贴
厌食模型
联合用药
Dingguier paste（丁桂儿脐贴）
model of anorexia
drug combination
