摘要
目的:探讨降脂合剂对高脂血症大鼠血脂谱、低密度脂蛋白(LDL)氧化易感性等的影响,并阐明其可能的机制。方法:将雄性Wistar大鼠60只随机等分为正常组、模型组、辛伐他汀组和降脂合剂高、中、低剂量组,除正常组外,其余各组喂饲高脂饲料建立高脂血症大鼠模型,同时按分组给予相应的预防药物,造模结束后取血测定大鼠血脂谱,LDL氧化易感性及大鼠肝脏丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px),肝脏LDL受体(LDL-R)mRNA的表达。结果:与模型组比较,降脂合剂各剂量组预防用药后,血脂水平得到不同程度的控制,Lag time和Tmax均明显延长,肝脏MDA水平明显降低,GSH-Px活力明显升高,肝脏LDL-R mRNA相对表达量明显升高,差异均有统计学意义(P<0.05,P<0.01)。结论:降脂合可较好的调节高脂血症大鼠血脂代谢并减轻脂质过氧化物对肝脏的损伤。
Objective： To study the effects of Lipid-lowering Mixture （LM） on blood lipid and low density lipoprotein （ LDL ） oxidative susceptibility in rats with hyperlipidemia, and to elucidate the possible mechanism. Methods： 60 male Wistar rats were randomly divided into normal group, model group, simvastalin and LM high, middle, low dose groups. Except the rats in normal group, the rats in the other groups were fed with a high fat diet to establish the hyperlipidemia rat model. At the same time giving the corresponding prophylactic medication according to the grouping. After the model established, the blood lipids and LDL susceptibility to oxidation, rat liver tissue malondialdehyde （MDA） and glutathione peroxidase （GSH-Px） and the mRNA expression of liver LDL receptor （LDL-R） in rats were tested. Results： Compared with the model group, after preventive medication, the blood lipid levels in all LM groups had been controled in varying degrees, Lag time and Tmax were significantly prolonged, MDA level in liver tissue was reduced, GSH-Px activity in the liver tissue was increased, and the relative expression levels in liver LDL-R mRNA increased significantly, the differences were statistically significant （P〈0.05, P〈0.01 ）. Conclusion： LM had good adjusting effect on blood lipid metabolism and protect liver by getting rid of peroxidation injury in hyperlipidemic rats.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2014年第1期263-265,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
湖北省教育厅科学研究计划资助课题(No.B20092905)~~
关键词
降脂合剂
高脂血症
血脂谱
低密度脂蛋白
Lipid-lowering Mixture
Hyperlipidemia
Lipid profile
Low density lipoprotein
