摘要
分析不同复合比例的头孢哌酮钠 磷酸钙骨水泥复合体的理化特性。其方法为制备含头孢哌酮钠与磷酸钙骨水泥质量比分别为 0 %、2 9%、4 8%、7 4%的复合材料 ,观察固化时间 ,用材料万能试验机测试抗压极限强度 ,用扫描电镜观察和分析超微结构等。结果表明 :磷酸钙骨水泥承载头孢哌酮钠后 ,随着所承载药物量的增加 ,固化时间和孔隙率的变化不显著 ;而抗压极限强度逐渐降低 ,四组抗压极限强度分别为 2 1 98± 1 0 6、2 1 38± 0 95、19 2 2± 1 11、13 5± 1 6 5MPa。磷酸钙骨水泥承载头孢哌酮钠药量在 0 % 4 8%之间对其理化特性无显著影响 ,复合体存在自然孔隙 ,具有较强的抗压性能 ,有望成为感染性骨缺损的理想修复材料。
This study was conducted to analyze the physicochemical properties of different mass ratio compounds of cefobid load calcium phosphate cement(CPC). The compounds of 0%, 2.9%, 4.8% and 7.4% mass ratio cefobid load CPC were made respectively. The setting time was observed; the compressive strength of compounds was measured by a material testing machine; the construction of compounds was observed by scanning electron microscopy(SEM) and analyzed by EIG. The results showed that both the setting time and the ratio of hole did not change obviously after the addition of cefobid, but the ultimate compressive strength decreased slowly and the results of the four groups were (21.98±1.06)MPa, (21.38±0.95)Mpa, (19.22±1.11)MPa and (13.5±1.65)MPa respectively. These data indicate there is no obvious effect on the physicochemical properties of calcium phosphate cement after the addition of cefobid between 0% and 4.8%. The compounds have irregular holes and hence a good ability of compressive strength. It might be a new bone grafting material for the reparation of infection related bone defects.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2000年第4期400-402,共3页
Journal of Biomedical Engineering
