摘要
目的：探讨选择性入肝血流阻断对肝脏能量代谢的影响。方法：用自行设计的可避免大鼠门静脉淤血的动物模型，通过分析阻断和恢复入肝血流后肝脏三磷酸腺苷、呼吸控制率、磷氧比值及动脉血酮体比值的变化与恢复过程，并与完全入肝血流阻断组及假手术组相对照。结果：选择性入肝血流阻断对肝脏能量代谢的变化及恢复过程与完全入肝血流阻断者差异有显著意义，前者的恢复明显好于后者。 结论：选择性入肝血流阻断对肝脏能量代谢的改变与恢复过程有积极的作用。
Objective: To evaluate the changes of hepatic energy metabolism by temporary occlusion of partial hepatopetal blood. Methods: The animal mode of partial hepatopetal blood occlusion (PBO) was established without portal stasis. The hepatic energy metabolism parameters including adenosine triphosphate, respiratory control ratio, P/O ratio, and arterial ketone bodies ratio were studied following 30 min ischemia or 1, 6, and 24 h of reperfusion. The total hepatopetal blood occlusion (TBO) and sham groups served as control. Results: The parameters of hepatic motochondrial function reflecting hepatic damage to ischemia-reperfusion showed different in PBO comparing with TBO group. The functional lesion was restored progressively in PBO-30 min group, but it was maintained low level in TBO-30 min group. Conclusion: The results suggest that it is beneficial to restoration of the hepatic energy metabolism in the ischemia-reperfusion injury by partial hepatopetal blood occlusion.
出处
《中华肝脏病杂志》
CAS
CSCD
2000年第6期358-360,共3页
Chinese Journal of Hepatology
