摘要
目的了解成人接种不同剂量乙型肝炎(乙肝)疫苗后HBsAg阳转率情况,评价不同剂量乙肝疫苗的免疫效果。方法选择经酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测确认乙肝5项指标(HBsAg、HBsAb、HBeAg、HBeAb、HBcAb)全阴的个体为调查对象,按0,1,6月免疫程序接种乙肝疫苗,完成全程免疫1个月后检测HBsAb。结果 HBsAb阳性545人HBsAb阳转率69.3%,高剂量组的调查对象HBsAb阳转率81.3%高于低剂量组的61.9%,且差异有统计学意(x2=32.84,P<0.001)。HBsAb阳转率在年龄组、性别、文化程度、接种剂量等方面的差异均有统计学意义(均有P<0.05),而在民族、职业、婚姻状况等方面差异均无统计学意义(均有P>0.05)。两种剂量的乙肝疫苗接种后均未出现明显的不良反应。结论按照同样的接种程序全程接种乙肝疫苗时,高剂量接种可以取得更好的免疫效果。
Objective To investigate the HBsAb positive rates in adults？ inoculated with different doses of hepati- tis B vaccine and to evaluate the immune effects of different doses of hepatitis B vaccine. Methods People whose five in- dexes of hepatitis B （HBsAg, HBsAb, HBeAg, HBeAb, HBcAb） were all negative tested by ELISA assay were selected, Hepatitis B vaccine was inoculated for 0, 1,6 months and HBsAb was tested after 1 months of the immunization. Results The HBsAb of 545 subjects were positive for HBsAb and the positive rate was 69. 3%. The positive rate of the high dose group was 81.3 %, which was significantly higher than that of the low dose with 61.9% （Z2 = 32. 84, P 〈 O. 001 ）. There were statistically significant differences in the positive rate of HBsAb among different age groups, genders, levels of educa- tion,inoculation doses. There were no statistical significances in different nationalities, marital status and vocations. Two doses of Hepatitis B vaccine did not demonstrate obvious adverse reactions. Conclusions The high dose of f hepatitis B vaccine will achieve better immune effect than that of the low one within the same vaccination program.
出处
《中华疾病控制杂志》
CAS
北大核心
2014年第1期55-57,共3页
Chinese Journal of Disease Control & Prevention
基金
安徽省预防医学与公共卫生科研课题(2011Y0101)
关键词
肝炎
慢性
疫苗
流行病学研究
Hepatitis, chronic
Vaccines
Epidemiologic studies
