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基于 UPLC-代谢组学技术研究泽泻结合有氧运动对高脂血症大鼠的改善作用 被引量:5

UPLC-based metabonomics study on the ameliorative effect of Alismatis Rhizoma and aerobic exercise in hyperlipidemia rat
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摘要 法治作为治国理政的基本方式,既要求维护国家法制统一、关注人权保障,又要求衡量法律实施效果时注意区域特色。法制统一表现为规则公平,而规则公平是实现权利公平、机会公平的前提与基础。人权保障作为宪法原则,应落实在各个部门法中,刑事诉讼中的人权保障是重中之重,因为其涉及与公民生命权、自由权密切相关的被羁押者权、获得公正审判权等。人的成长与世界观形成会受到区域社会环境及性别、出身、职业、民族等因素的影响,法律实施在不同区域会有不同效果。 UPLC-based metabonomics and prevention therapy study on the ameliorative effect of the extract of Alismatis Rhizoma(AR) in combination with aerobic exercise in hyperlipidemia rat. The rats were raised by high fat diet for four weeks; meanwhile these rats were treated with AR and aerobic exercise for four weeks. The rats were executed and the blood samples were collected. The model of hypenlipemia was then established and the model was verified by UPLC method. The TC, TG, LDL-C and HDL-C of the serum were detected and the concentration of SOD, GSH-Px, CAT and MDA were also measured. According to metabonomic meth- od and biochemical parameters, the hyperlipemia rat model was successfully established in four weeks. The re- sults showed that AR with aerobic exercise could decrease remarkably the concentrations of LDL-C, TC and TG. The activity of GSH-Px, SOD and CAT in AR with aerobic exercise group is promoted and the level of MAD is decreased dramatically. AR in combination with aerobic exercise could treat the abnormity of serum lipid and has obviously anti-lipoperoxidation effect. The metabonomic result showed the model of hypenlipemia was then established. Metabolomics could be a new method for studying the therapeutic effect of drug or aero- bic exercise.
作者 刘丹冰
机构地区 西北大学法学院
出处 《西北大学学报(哲学社会科学版)》 CAS CSSCI 北大核心 2014年第1期83-87,共5页 Journal of Northwest University:Philosophy and Social Sciences Edition
基金 国家自然科学基金资助项目(81001622) 陕西省国际合作基金资助项目(2013KW31-01) 西北大学本科教学质量与教学改革工程基金资助项目(JX13037)
关键词 公平 法治国家 被羁押者权 物质条件 Alismatis Rhizoma metabonomics UPLC hyperlipidemia aerobic exercise
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参考文献9

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