摘要
目的探讨两种剂量氯吡格雷对急性脑血栓患者溶栓的效果及安全性。方法选取2011年10月-2012年10月本院收治的150例首次发病的急性脑血栓患者，将所有病例随机分为观察1组（n=50）、观察2组（n=50）及对照组（n=50），所有患者冠状动脉造影术前均服用阿司匹林300mg，1次／d，观察组在对照组的基础上分别服用氯吡格雷300、600mg，1次／d。分别测定花生四烯酸（AA）、二磷酸腺苷（ADP）诱导的血小板抑制率。随访6个月内各组患者的不良反应发生情况。结果观察1组患者的收缩压、舒张压、三酰甘油均低于对照组，ADP及AA诱导的抑制率均高于对照组，差异有统计学意义（P〈0．05）；两组总胆同醇、低密度脂蛋白水平比较，差异无统计学意义（P〉0．05）。两组不良反应差异无统计学意义（P〉0．05）。观察l组和观察2组患者上述各指标差异无统计学意义（P〉0．05）。结论氯吡格雷300mg即可明显改善急性脑血栓患者的溶栓状况，效果显著，且安全系数高，值得临床推广使用。
Objective To study the thrombolysis effect and the safety evaluation of clopidogrel of clinical patients with acute cerebral thrombus. Methods 150 patients with acute cerebral thrombosis were selected in our hospital from Oc- tober 2011 to October 2011,they were randomly divided into observation 1 group （n=50）,observation 2 group （n=50） and control group （n=50）,all patients before coronary angiography took aspirin of 300 rag, 1 d for once,the observation group on the basis of the control group took 300 mg and 600 mg of clopidogrel,1 d for once. Arachidonic acid （AA） and the ADP induced platelet inhibition rate were separately measured.Adverse reactions occured for 6 months two groups of patients were followed up. Results Three acyl glycerin, systolic pressure, diastolic blood pressure in the observation 1 group was lower than that of the control group respectively,and the adenosine diphosphate and inhibition rate induced by arachidonic acid was higher than that of the control group respectively,the difference were statistically significant （P〈0.05）;Two groups of total cholesterol,low density lipoprotein cholesterol level,there was no statistically significant differ- ence （P〉0.05）.There was no statistically significant difference of adverse reactions in two groups （P〉0.05）.There was no statistically significant difference between the observation 1 group and observation 2 group （P〉0.05）. Conclusion Clopidogrel of 300 mg can obviously improve formulations thrombolysis in cerebral thrombosis patients,the effect is re- markable,and the safety factor is high,which is worth popularizing in clinical use.
出处
《中国当代医药》
2014年第2期40-42,共3页
China Modern Medicine
关键词
氯吡格雷
急性脑血栓
溶栓效果
安全性评价
Clopidogrel
Acute cerebral thrombus
Thrombolysis effect
Safety evaluation
