摘要
目的探讨绞股蓝皂苷提取物(gypenoside,GYP)对痛风性关节炎的预防,以及对相关炎性疼痛的镇痛作用。方法采用痛风性关节炎大鼠模型和5-HT致痛小鼠模型,通过行为学观察、生化指标检测等,评价GYP对炎性疼痛的镇痛作用和机制。结果 GYP可以通过多种途径包括抑制5-HT的生成,降低外周系统自由结合各种受体的游离5-HT浓度,及抑制5-HT1B受体活性。结论 GYP可能对痛风性关节炎相关的炎性疼痛发挥镇痛作用。
Objective This investigation focused on the prevention of gouty arthritis, and analgesic action on inflammatory pain by gypenoside. Methods Behavioral observation and biochemical analysis were used to evaluate analgesic effects of gypenoside and the mechanism on inflammatory pain in gouty arthritis rats and mice induced by 5-HT. Results Gypenoside had analgesic effect on inflammatory pain in gouty arthritis by a variety of ways, such as inhibiting the production of 5 - HT, reducing the concentration of free 5 - HT and suppressing 5 - HT1B receptor activity. Conclusion Gypenoside can be widely used as raw materials of functional food to improve the health of patients with gout. [ACTA NUTRIMENTA SINICA, 2013,35（6）：594-598,603]
出处
《营养学报》
CAS
CSCD
北大核心
2013年第6期594-598,603,共6页
Acta Nutrimenta Sinica
