摘要
乳腺癌转移抑制因子1(BRMS1)能抑制肿瘤转移并与肿瘤预后密切相关。BRMS1的卷曲螺旋结构能与分选连接蛋白6(SNX6)富含AT的结构域一起形成六聚体,而核定位信号2(NLS2)帮助BRMS1发挥转移抑制作用。BRMS1作为mSin3:组蛋白去乙酰化酶复合体(mSin3:HDAC)中的一员,能抑制核转录因子-κB(NF-κB)及其下游的尿激酶型纤溶酶原激活剂(uPA)、骨桥蛋白(OPN)和表皮生长因子受体(EGFR)等信号通路,恢复同型间细胞连接蛋白的表达,促进或抑制肿瘤转移相关的miRNA表达,从而对卵巢癌、黑色素瘤、非小细胞肺癌等多种肿瘤的转移起到抑制作用。该文对有关BRMS1介导的抑制肿瘤转移及其主要机制作一综述。
Breast cancer metastasis suppressor 1 （BRMS1） serves as a tumor suppressor correlated with tumor metastasis and prognosis. The coiled-coil motifs of BRMS1 have the capability of homo-oligomerizing to form a trio of dimers and mediates physical association with the Sorting Nexin 6 （ SNX6）, and nuclear localization signal 2 （NLS2） is discovered critical to the suppressor function. BRMS1, by forming complexes with mSin-histone deacetylase complex （roSin： HDAC）, suppresses expression or activities of multiple downstream targets including nuclear factor-kappa B （ NF-κB）, urokinase-type plasminogen activator （ uPA）, osteopontin （ OPN）, and epidermal growth factor receptor （EGFR） as well as metastasis- promoting miRNA, which affect metastasis of ovarian cancer, melanoma, and non-small cell lung cancer. In this article, recent advances on BRMS1 suppression metastasis are reviewed.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2014年第1期121-125,共5页
Journal of Shanghai Jiao tong University:Medical Science
