摘要
目的比较中波高能紫外线和308nm准分子激光治疗白癜风的短期疗效。方法中波高能紫外线组患者40例，每周照射2次；308nm准分子激光组40例，每周1次。评估两组治疗8周后的皮损复色情况。结果经过8周的阶段治疗，中波高能紫外线组有83．6％皮损可出现不同程度的复色反应，达显效以上复色为42．1％；308nm准分子激光组86．1％有皮损不同程度色素生成，达到显效以上为50％。对于面部白癜风皮损中波高能紫外线的疗效低于308nm准分子激光（x2=4．32，P〈0．05），在其余部位两组有效率差异无统计学意义。在皮损起始复色的累积剂量方面，两者差异无统计学意义（t=0．89，P〉0．05），在达到显效以上复色方面，高能中波紫外线的治疗次数和累积剂量明显多于308nm准分子激光（P〈0．01）。两者均适用于儿童患者及活动期皮损。结论中波高能紫外线或308l＇lm准分子激光治疗白癜风均可在短期内起效且安全，308nm准分子激光疗效更明显。
Objective To compare the short-term efficacy of high-intensity ultraviolet B （UVB） versus 308-nm excimer laser for the treatment of vitiligo. Methods Eighty patients with vitiligo were equally divided into two groups to be treated with high-intensity UVB twice a week or 308-nm excimer laser once a week for eight weeks. Repigmentation was evaluated at the end of the treatment. Results After eight weeks of treatment, repigmentation of different degrees was observed in 83.6% and 86.1%, and marked repigmentation in 42.1% and 50%, of the UVB- and excimer laser-treated lesions, respectively. The response rate was significantly lower in facial lesions receiving high-intensity UVB radiation than in those receiving excimer laser radiation （49.1% vs. 68.4%, X2 = 4.32, P 〈 0.05）, but similar at the other body sites between the two treatment （all P 〉 0.05）. The cumulative dosage required for initial repigmentation was similar between high-intensity UVB and 308-nm excimer laser （t = 0.89, P 〉 0.05）, while the treatment sessions and cumulative dosage required for marked or better repigmentation were significantly increased in UVB- compared with excimer laser-treated lesions （both P 〈 0.01）. In addition, both high-intensity UVB and 308-nm excimer laser were suitable for childhood and active vitiligo. Conclusions Both high-intensity UVB and 308-rim excimer laser are safe and effective in the treatment of vitiligo with rapid onset of action, and the latter appears to be superior to the former in efficacy.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2014年第1期59-61,共3页
Chinese Journal of Dermatology
关键词
白癜风
准分子激光
紫外线
Vitiligo
Excimer lasers
Ultraviolet rays
