摘要
【摘要1目的探讨我国目前艾滋病（acquired immune deficiencysyndrome，AIDS）患者采用的一线高效抗逆转录病毒疗法（highlyactiveantiretroviraltherapy，HAART）治疗方案对AIDS患者颈动脉弹性的影响。方法选取AIDS患者100例，非治疗组、HAART治疗组患者各50例，健康志愿者50例为对照组，行右侧颈动脉内一中膜厚度（IMT）测量和动脉弹性测量。结果对照组、AIDS治疗组和非治疗组三组间IMT比较差异无统计学意义（P〉0．05）；与对照组比较，AIDS治疗组和非治疗组颈动脉顺应性（CC）降低，僵硬度（8）、脉搏波传导速度（PwV）升高，差异具有统计学意义（P〈0．05）；AIDS治疗组和非治疗组间IMT、CC、8、PwV差异无统计学意义（P〉0．05）。结论AIDS患者在未出现颈动脉IMT增厚的早期阶段，其弹性功能已减低。目前国内AIDS治疗采用的一线HAART治疗方案，在用药依从性好（80％以上）、无严重其他系统并发症的轻症AIDS患者中较长期应用以来，未见对其动脉弹性功能造成明显不良影响。
Objective To evaluate the effect of highly active antiretroviral therapy （HAART） on carotid artery stiffness in acquired immune deficiency syndrome （AIDS） patients. Methods 100 AIDS patients were enrolled in this study, and were divided into un-therapy group（ n = 50） and HAART group （n = 50）,50 cases healthy people as control group. Carotid artery QIMT and QAS was examined and the intima media thiekness（IMT） and stiffness parameters were obtained. Results There was no statistically significance of IMT in three groups（ P ~0.05）. Comprare to the control group, compliance coefficent（CC） of un-therapy group and HAART group were decreased, stiffness 13 and pulse wave velocity（PWV） were increased,and there were statistically differences（ P d0.05）. But between un-therapy group and H AART group,there were no statistically differences of stiffness parameters（ P ~0.05）. Conclusions The carotid artery stiffness had reduced before IMT thicken in AIDS patients. There was no association between first- line HAART and carotid artery stiffness in mild AIDS patients.
出处
《中华超声影像学杂志》
CSCD
北大核心
2014年第1期24-26,共3页
Chinese Journal of Ultrasonography
关键词
超声检查
颈动脉
弹性
获得性免疫缺陷综合征
抗逆转录病毒治疗
高效
Ultrasonography
Carotid artery
Elasticity
Acquired immunodeficiency syndrome
Antiretroviral therapy, highly active
