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不同保护剂对313nm激发光下核黄素光化学法细菌灭活能力的影响 被引量:2

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摘要 目的研究313nm激发光下核黄素光化学法对细菌的灭活作用,探究灭活处理过程中不同保护剂以及盛装材料对灭活效果的影响。方法在核黄素光化学细菌灭活处理过程中加入不同浓度的血液成分保护剂:甘露醇、维生素C、色氨酸、组氨酸,探讨它们对细菌灭活效果的影响;通过细胞培养板与PVC血袋2种盛装材料探讨不同器具对细菌灭活效果的影响。结果在313nm光源激发下,核黄素光化学作用能使血袋中大肠杆菌及表皮葡萄球菌下降3 log/mL。所有保护剂对大肠杆菌和表皮葡萄球菌的灭活效果均无显著影响。液层厚度对灭活效果有重要影响。结论各保护剂对细菌灭活无不良影响,可用于进一步血液成分功能的保护研究。
出处 《中国输血杂志》 CAS CSCD 北大核心 2013年第12期1178-1180,共3页 Chinese Journal of Blood Transfusion
基金 上海市公共卫生重点学科建设项目(12GWZX0201) 上海市卫生局课题(20124423)
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参考文献11

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