摘要
目的 :研究 p16蛋白与人脑星形细胞瘤发病和预后的关系。方法 :用 SP免疫组化法观察星形细胞瘤中p16蛋白的表达情况。结果 :p16蛋白在 39例星形细胞瘤中表达的缺失率为 71.8% ,并且缺失率随星形细胞瘤恶性程度的增加而升高。术后各观察期内复发病例中的 p16蛋白缺失率明显高于未复发病例 (P <0 .0 5 )。结论 :p16蛋白表达的缺失与星形细胞瘤的发生有较密切的关系 ,在一定程度上可以提示它的恶性程度及预后。
Objective:Our aim was to study the relationship of p16 protein with the formation and prognosis of human astrocytoma. Methods:Thirty nine patients with astrocytoma were detected by S P immunohistochemical method.Results:Deletion rate of p16 protein in astrocytomas was 71.8% A significant difference of deletion rate existed between WHO grade Ⅰ,Ⅱ and WHO grade Ⅲ,Ⅳ(P<0.01).Conclusion:The deletion of p16 protein may have closely connection with the formation of astrocytoma. It can be useful in evaluating the malignant degree and prognosis in astrocytoma.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2000年第6期467-468,共2页
Journal of China Medical University
