摘要
目的 研究中年 2型糖尿病 (NIDDM)患者的记忆功能和糖尿病的关系 ,以更有效地教育和治疗患者。方法 对象为中年 (4 0～ 6 0岁 ) NIDDM患者和人口学因素相似的非糖尿病人各 30名 ,排除可能影响记忆功能的脑血管疾病、药物和酒精滥用、痴呆和严重的精神疾病等 ,糖尿病人测查当日均无低血糖发作。采用韦氏记忆量表测查记忆功能 ;EPQ、SAS、SDS测查人格和情绪状态 ;患者和对照组各 11人做脑血流灌注显像检查 (SPECT)。结果 糖尿病组记忆测验各项成绩均低于对照组 (P <0 .0 5 )、焦虑和抑郁情绪较对照组严重 (P <0 .0 5 )。SPECT显示 NIDDM患者确实存在着局部脑血流的低灌注。结论中年 NIDDM患者确实存在记忆力的下降 ,局部脑血流的低灌注可能是原因之一。患者的心身因素与记忆功能相关。心理健康可以促进记忆等认知功能的提高。
Objective To study the relationship between type 2 diabetes and memory function Methods Wechsler Memory Scale Revised(WMS R) were used to examine the ability of memory in 30 NIDDM middle aged patients and controls All participants would complete EPQ, the Self Rating Depression Scale(SDS) and Self Rating Anxiety Scale (SAS) brain blood perfusion of 11 patients and 11 control subjects were evaluated by means of SPECT Results Broad disturbances with the memory scales in diabetes were found(P<0 05) NIDDM patients were more depressive and anxious than the control subjects The results of SPECT demonstrate the existence of regional hypo perfusion of brain blood of patients with type 2 diabetes mellitus Conclusion Middle aged people with type 2 diabetes really had decrement of the ability of memory in some extend The hypo perfusion of cerebral blood flow could be, at least in part, the possible explanatory mechanism which result in the cognitive dysfunction of the middle aged patients The medical condition and mental health were all related to the memorial impairment that has been associated with diabetes
出处
《中国行为医学科学》
CSCD
2000年第5期336-338,共3页
Chinese Journal of Behavioral Medical Science
关键词
NIDDM
记忆功能
功能性脑血流灌注显像
Type 2 diabetes Memory ability Single photon emission computed tomography(SPECT)
