摘要
2002年美国妇女健康干预(Women’s Health Initiative,WHI)的发表使绝经激素治疗进入了一个低谷。近10年来该领域取得了重大进展,目前的观点已经有很大的不同。该文在具体介绍WHI研究后,着重介绍了该领域10年来的最重要研究,包括WHI再分析、丹麦的DOPS研究、欧洲的EURAS-HRT研究等,突出了这10年来最重要的进展为"窗口期"理论和孕激素选择。最后介绍了2013年关于绝经激素治疗(menopausal hormone therapy,MHT)的国际共识要点。
Publication of the first results from the Women＇ s Health Initiative （WHI） trial in 2002 made menopausal management fall to peak negative sentiment. Over the past decade significant progress have been made in this area. The opinions about menopausal management are distinguished differentfrom those around 2002. After discussion about de- sign and limitations of WHI, the most important studies in the recent decade, e. g. reanalysis of WHI, Danish Osteoporosis Prevention Study and Eu- ropean active surveillance study of women taking HRT were detailed introduced. We emphasized that ＂ opportunity window＂ theory and progestogens effects were the most important progress in the past decade. At the end of this article key points from in- ternational consensus about menopausal hormone therapy in 2013 were listed.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2014年第1期38-40,共3页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
绝经激素治疗
激素补充治疗
窗口期理
论
孕激素
menopausal hormone therapy
hormonereplacement therapy
＂opportunity window＂ theory
progestogen
