摘要
目的 观察雌激素对女性冠心病患者血脂的影响,并探讨应用雌激素的利弊。方法 选46例绝经妇女冠心病患者为观察组,38例绝经后健康妇女作为对照组,以上二组中的患者随机分为干预组和安慰剂组,分别予以尼尔雌醇(每月2mg/次)或安慰剂(每月1片/次)治疗6个月,治疗前及治疗6个月后,分别测血总胆固醇(TC)、甘油三酯(TG)和高密度脂蛋白(HDL)及低密度脂蛋白(LDL)水平。结果 经过尼尔雌醇6个月干预治疗后,血清HDL-C水平明显升高(P<0.05)。血清LDL-C水平明显下降(P<0.05)。结论 尼尔雌醇替代治疗能改善血脂异常,有利于绝经后冠心病妇女的心血管保护作用。
Objective To study the effects of estrogen action on lipid of the menopausal female patients with coronary heart disease (CHD) . Methods The study group (n = 46) and control group (n = 38) were treated with estrogen nilestriol ( 2mg per month) and placebo respectively for 6 months. Total cholesterol ( TC ) , triglyceride ( TG ) , high density lipopro-tein-cholesterol (HDL-C) and low density
lipoprotein-cholesterol(LDL-C) were measured before treatment and after treatment 6 monthes. Results Serum HDL-C level was increased significantly (P<0. 05) and serum LDL-C level decreased markedly (P <0. 05) by treatment of estrogen nilestriol for 6 months. Conclusion The treatment by nilestriol can improve lipid metab-olization in menopausal women with CHD
出处
《实用心脑肺血管病杂志》
2000年第4期205-206,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
雌激素
女性
冠心病
血脂
治疗
Estrogen women Coronary heart disease Lipids
