摘要
背景:纳米级羟基磷灰石有利于改善骨植入体的力学性能。目的:观察纳米羟基磷灰石人工骨修复塌陷型胫骨平台骨折的临床效果。方法:回顾性分析2010年3月至2012年9月,采用纳米羟基磷灰石人工骨治疗胫骨平台塌陷骨折14例合并骨缺损患者的临床资料,骨缺损范围为1.5 cm×1.0 cm-3.1 cm×4.5 cm,人工骨植入量为5-14 g。分别在治疗后1周、1个月和3个月进行临床和X射线片检查,观察治疗效果,HSS评分系统评估膝关节功能恢复情况。结果与结论:随访12-27个月,除1例患者伤口处有少量渗出外,其余13例患者无术后发热、伤口红肿及过敏现象,伤口一期愈合,未发生切口感染等并发症。治疗后3个月观察,骨缺损区纳米羟基磷灰石与宿主骨直接愈合,相容性好,与原骨界面间无间隙,术后观察未见不良反应,治疗后1年HSS评分为(88.7±4.3)分。表明纳米羟基磷灰石人工骨具有良好的生物相容性,生物力学良好,对于塌陷型胫骨平台骨折是一种较理想的骨缺损修复材料。
BACKGROUND： Nano-hydroxyapatite helps to improve the mechanical properties of bone implants. OBJECTIVE： To study the clinical effect of nano-hydroxyapatite artificial bone on collapsed fracture of the tibial plateau. METHODS： Fourteen cases of collapsed fracture of the tibial plateau combined with bone defects from March 2010 to September 2012 were analyzed retrospectively. The bone defect range was from 1.5 cmx1.0 cm to 3.1 cmx4.5 cm. All patients were treated with nano-hydroxyapatite artificial bone at an implant amount of 5-14 g. Clinical and X-ray observations were applied at 1 week, 1 month and 3 months postoperatively. Hospital for Special Surgery scores were employed for recovery of knee function. RESULTS AND CONCLUSION： The patients were followed up for 12-27 months. Except for one case of a smal amount of wound exudates, no general side effects occurred in 13 cases. X-ray photo showed an integrity interface between nano-hydroxyapatite artificial bone and host bone at 3 months after treatment. Primary healing was obtained in all cases without any complications. Hospital for Special Surgery score was increased to （88.7＋4.3） points at 1 year later. These findings indicate that the nano-hydroxyapatite artificial bone has a good biocompatibility and biomechanics, and it may be an ideal artificial bone for repairing collapsed fractures of the tibial plateau.
出处
《中国组织工程研究》
CAS
CSCD
2013年第51期8863-8868,共6页
Chinese Journal of Tissue Engineering Research
基金
深圳市科技研发项目(GJHZ20130412153906739
CXZZ20130321152713220)
广东省医学科研基金项目(B2012320)
广东省教育厅育才项目(2012LYM_0120)~~
