摘要
目的 :为探讨细胞毒素相关蛋白 (Cag A)与幽门螺杆菌 (Hp)相关胃十二指肠疾病的关系。方法 :应用间接 EL ISA法定性检测 170例胃镜受检者 Cag AHp Ig G抗体。结果 :170例受检者中 ,Hp感染者 10 6例 ,其中 Cag A阳性 6 9例 ,阳性率为 6 5 .0 9% ,Hp感染的 DU、GU、GCa患者 Cag A阳性率明显高于 Hp感染的 CG患者 (P <0 .0 5 ) ,DU、GU、GCa组间无明显差别 (P >0 .0 5 )。结论 :提示 Cag A与 Hp相关的严重胃十二指肠疾病密切相关。
To investigate the relationship between cytotoxin associated protein(CagA) and H.pylori related gastroduodenal disease. The gastric antral mucosal biopsies and serum were obtained from 170 patients. Serum CagA antibodies were detected by an indirect ELISA assay. The results showed that 106 of 170 patients were infected by H. pylori, 69 of 106 H.pylori infected patients were CagA sero-positive (65.09%). Serologic recognition of CagA protein is significantly more frequent in patients who were H.pylori infected with ulcer disease and gastric cancer than in those with gastritis alone (P<0.05), but there was no statistical difference between duodenal bulbar ulcer、 gastric ulcer and gastric cancer groups (P>0.05). These results indicated that a clear correlation exists between CagA and H. pylori-related severe gastroduodenal disease. \ \
出处
《广西医学》
CAS
2000年第6期1180-1182,共3页
Guangxi Medical Journal
