摘要
目的 :研究旱莲草乙酸乙酯总提物 (TAEEP)对正常及免疫抑制小鼠T淋巴细胞亚群的作用。方法 :采用正常及腹腔注射环磷酰胺 ( 60mg/kg)所致免疫功能低下小鼠模型 ,给予大、小剂量的TAEEP ,用流式细胞仪测定小鼠血T淋巴细胞CD4 +、CD8+亚群的比例。结果 :大、小剂量TAEEP均显著降低正常小鼠CD4 +亚群的比例 (P <0 .0 1) ,并可显著提高免疫低下小鼠CD4 +亚群比例 ,对于正常小鼠CD8+亚群的比例 ,TAEEP的小剂量可显著降低其比例 (P <0 .0 5) ,而大剂量则显著提高其比例。结论 :旱莲草乙酸乙酯总提物对小鼠外周血T淋巴细胞亚群具有调节作用。
Objective:To explore the effect of Tethyl acetate Extract of Eclipta prostrata(TAEEP) on T lymphocyte subsets in normal and immunosuppressive mice.Method:By flow cytometer to determine the proportion of peripheral blood T lymphocyte subsets of normal and immunosuppressive mice treated with TAEEP.Result:Large and small dose of TAEEP can decrese drastically the proportion of CD + 4 subsets of normal mice and increase the proportion of CD + 4 subsets of immunosuppressive mice.Compared with the normal groups,the proportion of CD + 8 subsets can be increased significantly by the large dose of TAEEP,while be decreased by the small dose of TAEEP.Conclusion:TAEEP possess regulatory effects on peripheral T lymphocyte subsets of mice.
出处
《安徽中医学院学报》
CAS
2000年第6期52-53,共2页
Journal of Anhui Traditional Chinese Medical College
关键词
旱莲草
T淋巴细胞亚群
细胞免疫
Eclipta prostrata
T lymphocyte subsets
Cellular immunity
