摘要
目的探讨脑电生物反馈合并帕罗西汀治疗恐惧症的临床疗效。方法将100例恐惧症患者随机分为两组,各50例,对照组仅给予帕罗西汀药物治疗,研究组在对照组治疗基础上加用脑电生物反馈治疗,对两组患者临床疗效进行对比分析。结果研究组总有效率为92.0%(46/50),对照组总有效率为56.0%(28/50),两组比较,差异有统计学意义(P<0.01)。两组汉密顿焦虑量表(HAMA)总分在治疗第1、2、4、8周比较,差异有统计学意义(P<0.05或0.01)。两组世界卫生组织生活质量评定量表(WHOQOL-100)评分在治疗后均优于治疗前,在治疗第8周,研究组社会关系、独立性、心理及生理评分显著高于对照组,差异有统计学意义(P<0.05或0.01)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论脑电生物反馈合并帕罗西汀治疗恐惧症疗效较好,患者的生活质量有较大提高。
Objective To explore the clinical efficacy of paroxetine combined with electroencephalographic （EEG） biofeedback therapy for phobia. Methods One hundred patients with phobia were randomized into two groups （observation group and control group）, 50 cases in each group. The control group was only given paroxetine for treatment, while the observation group was added with EEG biofeedback therapy on the basis of control group. The clinical efficacy in the two groups was com- pared and analyzed. Results The total effective rate was 92.0% （46/50） in the observation group and 56.0% （28/50） in the con trol group, and the difference between the two groups was statistically significant（P〈0.01 ）. The scores of Hamilton anxiety scale （HAMA） on 1 st, 2nd, 4th, 8th week in the two groups had statistically significant difference （P〈0.05, or 0.01 ）. The scores of world healthy organization quality of life scale; （WHOQOL-100 ） in the two groups after treatment were prior to those before treatment. On the 8th week of treatment ,the scores of social relations ,independence ,psychology and physiology in the observation group were obviously higher than those in the control group with statistically significant difference （P〈0.05, or 0.01 ）. The difference of adverse reaction rate between the two groups had no statistical significance （P〉0.05）. Conclusion EEG biofeedback therapy combined with paroxetine is effective to patients with phobia, and living quality of the patients has increased a lot.
出处
《现代医药卫生》
2014年第1期17-18,20,共3页
Journal of Modern Medicine & Health
关键词
恐怖症
脑电描记术
帕罗西汀
临床对照试验
Phobic disorders
Electroencephalography
Paroxetine
Controlled clinical trial
