摘要
新生儿低出生体重与成年后2型糖尿病的高危性密切相关，其机制尚不明确。胎儿胰岛素假说指出：胰岛素是胎儿重要的生长激素，与胰岛素分泌减少及功能减弱有关的基因变异均可减缓胎儿生长并增加2型糖尿病的患病风险。作为研究复杂疾病遗传学的新兴手段，全基因组关联研究（GWAS）发现了许多与低出生体重及2型糖尿病有关的遗传位点。目前，已经证实与低出生体重相关的常见基因变异有LEKR1／CCNL1，ADCY5，CDKAL1，HHEX4DE；同时ADCY5，CDKAL1，HHEXqDE也是2型糖尿病的易感基因。
Low birth weight is associated with a higher risk of type 2 diabetes in later life,but the mechanisms are poorly understood.While the fetal insulin hypothesis indicates that insulin is an important growth hormone for fetal, genetic variants that are associated with the decrease of insulin secretion and function may account for some of the observed correlation between low birth weight and increased risk of type 2 diabetes. As a new means of studying complex disease genetics, genome-wide association studies （GWAS） has found many genetic loci which are related to low birth weight and type 2 diabetes. At present, it has confirmed that common genetic variants associated with low birth weight are LEKR1/CCNL1,ADCYS,CDKAL1, HHEX-IDE.Further more, ADCY5, CDKAL1 and HHEX-IDE are also susceptible genes of type 2 diabetes.
出处
《国际内分泌代谢杂志》
北大核心
2014年第1期63-66,共4页
International Journal of Endocrinology and Metabolism
关键词
低出生体重
2型糖尿病
遗传学
Low birth weight
Type 2 diabetes mellitus
Genetics
