摘要
目的探讨胎粪吸入综合征(MAS)与小儿哮喘发病的相关性。方法选取102例MAS患儿为MAS组,选同期出生羊水清亮足月正常新生儿200例为对照组,采用EILSA法对2组进行血清IgE含量检测;随访观察2组哮喘病发病情况,并进行肺功能及肺炎支原体(MP)、衣原体(CP)、呼吸合胞病毒(RSV)、流感病毒(IV)及副流感病毒(PIV)等抗体检测,了解其与哮喘的关系。结果 MAS组的哮喘患病率为26.8%,对照组为6.3%,2组比较有显著性差异(P<0.05);MAS组的IgE水平明显高于对照组(P<0.05);MAS组的MPIgM、CP-IgM、IV-IgM检出率均显著低于对照组(P均<0.05);MAS组的tPTEF/tE、vPTEF/vE下降程度比对照组更明显(P均<0.05)。结论 MAS与小儿喘息密切相关,MAS患儿发生喘息时下呼吸道阻塞更严重,建议有针对性地进行孕期干预,避免胎儿胎粪污染及宫内致敏,对降低小儿哮喘发生率有较大临床意义。
Objective It is to discuss the relationship between meconium aspiration syndrome （MAS） and infants asthma. Methods 102 cases of infants with MAS were chosen as MAS group and 200 infants without MAS as control group at the same term. The concentration of serum IgE was determined by EILSA in both groups. By follow-up visit, the incidence of asthma was observed, pulmonary function was detected , the levels of MP - IgM, CP - IgM, RSV - IgM, IV - IgM and ADV - IgM were determined, to analyze the correlation between MAS and infant asthma. Results Asthma incidence rate in MAS group was 26.8% , which was much higher than that of 6.3% in control group（ P 〈 0.05 ）. IgE level in MAS group was much higher than the control group （P〈0.05）. The detection rate of MP-IgM, CP-IgM, IV-IgM were much lower than that of the control group（ P 〈 0.05 ）. And the descending extent of tPTEF/tE and vPTEF/vE in MAS group was more obvious than that of control group（ P 〈 0.05 ）. Conclusion MAS is closely correlated with morbidity of infant asthma and the lower respiratory tract obstruction became more serious when asthma occurred in MAS infants, to strengthen early targeted intervention, avoid meco-nium polluted and sensitized in utero would be meaningful for reducing morbidity of asthma.
出处
《现代中西医结合杂志》
CAS
2014年第2期134-136,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
胎粪吸入综合征
哮喘
相关性
随访
meconium aspiration syndrome
asthma
relativity
follow-up
