摘要
目的 评价非小细胞肺癌 (NSCLC)术前支气管动脉灌注化疗 (BAI)近期疗效。方法 经影像学判断手术切除难度较大 ,或不能手术切除的中心型NSCLC患者 2 0例行前瞻性术前BAI。BAI后行手术切除。结果 BAI治疗前后TNM分类改变 5例 ,其中N下降 1例 ,5例均有T改变 ;临床分期下降 2例。PR 8例 ,缓解率为 40 % ,其中鳞癌 6例 ,腺癌 2例 ;NC 12例 ,其中腺癌 1例 ,其余为鳞癌。BAI前后肺不张改善的 9/ 12例 ( 75 % ) ;与周围组织关系密切或受侵改善的 6 / 15例 ( 37 5 % ) ;纵隔淋巴结肿大缩小的 12 / 18例 ( 6 6 6 7% )。结论 BAI作为NSCLC ,尤其是鳞癌的术前辅助治疗 ,具有一定的近期疗效 ,与其它辅助治疗具有同样重要的临床意义 ,是一种特殊的NSCLC新辅助化疗形式。BAI后CT扫描尚不能完全反应残存肿瘤及肿瘤坏死、纤维化等组织学方面的改变 ,具有局限性。CYFRA2 1
Objective To evaluate the short\|term results of preoperative bronchial arterial infusion (BAI) in central non\|small cell lung cancer (NSCLC). Methods 20 patients who were confirmed unresectable central NSCLC by imaging underwent preoperative BAI. Results With preoperative BAI,decreasing in T and N stage was achieved in 5 and 1 case respectively,decreasing in clinical stage was achieved in 2 cases. 6 cases with squamous carcinoma, 2 cases with adenocarcinoma showed a partial response (PR,40%).Mediastinal lymph nodes were reduced in diameter in 12 cases (66 67%). Conclusion BAI was proved highly effective with local control before resection for central NSCLC,especially in patients with squamous carcinoma. Preoperative BAI was recommended as a specific neoadjuvant chemotherapy for central NSCLC.CT scan was limited in predicting the pathological changes post\|BAI.CYFRA 21\|1 and dynamic MRI were useful methods to evaluate clinical status and prognosis post\|BAI of patients with NSCLC. [
出处
《中国医学影像技术》
CSCD
北大核心
2000年第11期933-935,共3页
Chinese Journal of Medical Imaging Technology
基金
国家"九五"攻关资助项目 (96 90 7 0 3 0 3)
关键词
非小细胞肺癌
支气管动脉灌注
化疗
疗效
Non\|small cell lung cancer
Bronchial arterial infusion
Neoadjuvant chemotherapy
