摘要
目的:观察胃炎结颗粒对实验性慢性胃炎大鼠的治疗作用。方法:Wistar大鼠60只,选取10只为空白组,常规饲养;剩余50只采用0.02%氨水自由饮用制备大鼠实验性慢性胃炎模型。将模型大鼠随机分为模型组、维霉素组、胃炎结大、中、小剂量组,每组10只。对各组给予相对应药物治疗,测定各组大鼠胃液PH值及胃蛋白酶活性、胃腺管长度、表面上皮层厚度、胃黏膜PAS染色阳性层厚度,并进行壁细胞计数,比较各组结果。结果:胃炎结颗粒可降低胃液PH值和胃蛋白酶活性,使黏膜上皮病变减轻,PAS阳性层增多,黏膜厚度增加,壁细胞计数升高,且以胃炎结大剂量组疗效为最佳。结论:胃炎结颗粒对氨水诱发的大鼠实验性慢性胃炎具有明显的保护作用。
Objective：To observe the therapeutic effect of Weiyanjie granules in rats with experimental chronic gastritis. Methods： Ten of 60 Wistar rats were selected as blank group to be conventionally fed;the other 50 rats freely drank 0. 02% ammonia water to establish a rat model of chronic gastritis. The rats with chronic gastritis were randomly and equally divided into model group, vitacoenzyme group, and high - , middle - , and low - dose Weiyanjie groups. All groups received respective treatments. The pH value of gastric juice, pepsin activity, gland duct length, surface epithelium thickness, thickness of gastric mucosa with positive PAS staining, and parietal cell count were determined and compared between groups. Results：Weiyanjie granules decreased the pH value of gastric juice and pepsin activity, alleviated gastric mucosal lesion,increased the thickness of gastric mucosa with positive PAS staining and mucosal thickness, and increased parietal cell count, and the high - dose Weiyanjie group had the best treatment outcome. Conclusion ： Weiyanjie granules have a significant protective effect in rats with experimental chronic gastritis induced by ammonia water.
出处
《湖南中医杂志》
2013年第12期128-130,共3页
Hunan Journal of Traditional Chinese Medicine
关键词
慢性胃炎
胃炎结颗粒
大鼠
实验研究
chronic gastritis
Weiyanjie granule
rat
experimental study
