摘要
目的分析抗感染药物致老年人药品不良反应(ADR)报告相关因素,促进临床合理应用抗感染药物。方法统计该院2006—2012年上报的抗感染药物致老年人药品不良反应报告,从患者情况、抗感染药物的种类、给药途径、剂量等方面进行回顾性分析。结果 183例抗感染药物致老年人药品不良反应报告中,喹诺酮类药物不良反应例数最多,占51.91%;给药途径以静脉给药所占比例最大占79.78%;未根据老年人肾功能进行减量的占39.44%。结论抗感染药物致老年人不良反应/事件与药物种类、给药途径、给药剂量等多种因素有关,不合理使用抗感染药物是药品不良反应/事件产生的主要因素之一,应加强老年人抗感染药物使用的管理。
Objective To study factors related to anti-infective-induced adverse drug reactions/events in elderly patients in order to promote rational drug use. Methods 183 cases of adverse drug reactions/events reported in our hospital from January 2006 to December 2012 were analyzed retrospectively. Results 183 cases that occurred among the elderly were induced by anti-infective agents. FQNs were the primary anti-infective agents which induced ADRs in the elderly（51. 91%）. The main dosing route of the anti-infective agents was iv injection（79. 78%）. Dose was not adjusted according to the renal function of patients in 74 cases（39. 44%）. Conclusion ADRs are related to a variety of factors,such as the category of anti-intensive agents and route and time of administration. Irrational use of anti-infective agents is one of the main causes of adverse drug reactions/events. More attention should be paid to the adverse reactions of anti-infective agents,especially in elderly patients.
出处
《解放军药学学报》
CAS
2013年第6期571-574,共4页
Pharmaceutical Journal of Chinese People's Liberation Army
关键词
老年人
因素分析
不合理用药
预防
elderly patient
factor analysis
irrational use of drugs
prevention
