摘要
MicroRNA是新近发现的一种小分子RNA，参与了机体多种疾病的发生发展。近年研究发现，mi—croRNA通过多种调控机制参与了微血管病变的发生发展。深入了解其调控机制不仅能够丰富人们对微血管病变的认识，对微血管病变的诊疗也具有重要的指导意义。现就microRNA在微血管病变发生发展中的调控机制予以概述。
Microangiopathy is characterized by capillary basement membrane thickening and microthrombus formation. The process of microangiopathy involves multiple organs and tissues, and seriously endangers the patients＇ health and quality of life＇during the later stage. Recent evidence shows that microRNAs play an important role in the regula- tory mechanism of microangiopathy, including inflammatory response, oxidative stress, abnormalities of glucose and lipid metabolism, abnormal activation of the rennin-angiotensin system and so on. The regulatory mechanism has unique features of microangiopathy in different organs. At present, more and more attention has been paid to the roles of microRNAs in the pathogenesis of microangiopathy.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2013年第12期2292-2296,共5页
Chinese Journal of Pathophysiology
基金
广东省自然科学基金博士启动项目(No.S2012040007106)
广东省医学科研基金资助项目(No.B2013252)
