摘要
肝再生实际上是肝脏在组织发生缺损后进行损伤修复的代偿性增生过程,其机制非常复杂,多种细胞因子、核受体和信号通路参与其中.法尼醇X受体(farnesoid X receptor,FXR)是需配体激活的转录因子,属于代谢性核受体,在肝脏胆汁酸、脂质、糖代谢过程中起着重要的调节作用.近来研究发现,核受体FXR对肝脏再生至关重要.FXR的激活通过促进部分肝切除后肝细胞的增殖,直接促进肝脏再生;通过调节胆汁酸的合成与转运,避免切除后胆汁酸过多引起的肝组织损伤;其代谢调节作用有益于肝再生进程.本文着重对FXR调控肝再生的机制及促肝再生药物靶向治疗做一综述.
Liver regeneration is a practical compensatory re- growth in response to the loss of hepatic tissue. The mechanism of liver regeneration is very com- plex and many cytokines, transcription factors and signaling pathways are involved in this process. The farnesoid X receptor （FXR） is a member of metabolic nuclear receptors of intracellular ligand- activated transcription factors and plays an im- portant role in metabolism of bile acids, lipid and glucose. In addition, it has been recently reported that FXR is crucial for liver regeneration. FXR ac- tivation directly promotes liver regeneration by regulating hepatocyte proliferation and regulates synthesis and transport of bile acids to prevent the liver from injury by increased bile acids after hepatectomy. The metabolic regulation of FXR is beneficial to liver regeneration. This review fo- cuses on the mechanism of FXR regulation of liver regeneration and targeted drugs.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第34期3767-3774,共8页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
Nos.81273580
81302826~~
关键词
法尼醇X受体
肝再生
胆汁酸
靶向治疗
Farnesoid X receptor
Liver regenera-tion
Bile acids
Targeted therapy
