摘要
坏死性小肠结肠炎（necrotizing enterocolitis,NEC）是一种常见且严重的胃肠道疾病,主要发生在早产儿.尽管采取了诸多措施,NEC的病死率仍然很高.近年来,诸多研究显示肝素结合表皮生长因子样生长因子（heparin-binding epidermal growth factor-like growth factor,HB-EGF）可以保护肠道上皮细胞免受多种伤害.并且,在成年大鼠肠道缺血再灌注损伤模型和新生NEC模型鼠进行的实验显示,HB-EGF可以保护肠道免受损伤.这些研究为NEC的治疗和预防提供了一个新的研究方向.
Necrotizing enterocolitis（NEC） is a common and devastating gastrointestinal disease that occurs predominantly in premature infants.Despite various advances in management,the mortality of this disease remains high.During the last decade,studies have shown that heparin-binding epidermal growth factor-like growth factor （HB-EGF）,can protect intestinal epithelial cells from various forms of injury in vitro.Furthermore,studies using both an intestinal ischemia-reperfusion injury model in adult rats and neonatal rat model of NEC,have shown that HB-EGF can protect the intestines from injury.Present studies provide a new research direction in the prevention and treatment.
出处
《国际儿科学杂志》
2013年第6期585-588,共4页
International Journal of Pediatrics
