摘要
目的 观察抗结核组合药对HBVM阳性肺结核病人肝功能的影响。方法 比较HBVM阳性和阴性肺结核病人组合药治疗前后肝功能损害情况。结果 HBVM阳性病人肝损率比阴性者明显增高 (P <0 .0 1) ;其中“模式Ⅰ”与“模式Ⅱ”病人肝损率差异不显著 (P >0 .0 5) ,而“模式Ⅰ +Ⅱ”病人肝损率比“模式Ⅲ”高 (P <0 .0 5)。结论 组合药致肝功能损害 ,HBVM阳性病人比阴性多见 ,尤以“模式Ⅰ、Ⅱ”病人更易发生 ,可能与用药前肝脏病理损害严重程度有关。
Objective To observe the effect on liver function in pulmonary tuberculosis with positive HBVM treated by antituberculotic combination.Methods Compare the damage to the liver function of the HBVM positive or negative tuberculosis patient before and after taking the antituberculotic combination.Results The damage to the liver function of the HBVM positive tuberculosis patient is much higher than negative tuberculosis patient( P<0.01 ),and the damage to the “Model Ⅰ”and “Model Ⅱ”patient varies little( P>0.05 ).But the damage to the liver function of “Model Ⅰ+Ⅱ”patients is higher than that of “Model Ⅲ”( P<0.05 ).Conclusion The antituberculotic combination will damage the liver function of HBVM positive tuberculosis patients and negative tuberculosis patients,“Model Ⅰ”and “Model Ⅱ”patients are easily affected.The combination drug must be taken carefully and comprehesive prevention measures must be taken ahead.
出处
《中国防痨杂志》
CAS
北大核心
2001年第1期30-32,共3页
Chinese Journal of Antituberculosis
