摘要
目的:探讨晚期食管癌应用PPF方案治疗的疗效与毒副作用.方法:平阳霉素(PYM)6mg/m^2肌注第1、4、8、11天,顺铂(PDD)40mg静滴第1～3天,5-氟脲嘧啶(5-Fu)500mg/m^2静滴第1～5天.3周重复.结果:治疗组有效率63.3%,对照组有效率36.7%,疗效有显著差异(x^2=4.27,P<0.05);主要毒副反应无显著性差异.结论:PPF方案对晚期食管癌有较好的疗效,毒副反应能耐受,可作为晚期食管癌的有效治疗方案.
Objective:To study the effects and side effects of PPF regimen in the treatment of advanced esophageal cancer. Methods :PYM 6mg/m2 was given by muscle infusion on day 1,4,8,11. 5 - Fu 500mg/m2 was given by intravenous infusion from day 1 to day PDD 5.40mg was given by intravenous infusion from day 1 to day 3. The therasy above recycled every 3 weeks. Re-sults : 30 cases were treated with PYM - PDD - 5 - Fu regimen with a response rate of 63.3 % . But 30 cases were treated with 5 - Fu - PDD regimen with a response rate of 36.7 % . There was significant difference between the two groups curative effects (?^(2) = 4.27, P<0.05). There was no significant difference in toxic reaction. Conclusions:PPF regimen can be regarded as an effective regimen for advanced esophageal cancer, and its toxicity is tolerable.
出处
《临床肿瘤学杂志》
CAS
2000年第4期281-283,共3页
Chinese Clinical Oncology
关键词
晚期
食管癌
联合化疗
PPF方案
Advanced cancer Esophageal cancer Combined chemotherapy
