摘要
目的 :为了弄清慢性乙型肝炎病程中乙型肝炎病毒e系统状态和纤维化进展及其癌变的关系。方法 :分别比较慢性乙型肝炎不同纤维化分期以及原发性肝癌组的HBeAg或抗 HBe阳性率。结果 :HBeAg阳性率在慢性乙型肝炎纤维化S1、S2、S3和S4分期中分别为 85 2 % (2 3/2 7)、72 7% (2 4/33)、6 3 3% (19/30 )和 5 0 % (12 /2 4) ,原发性肝癌组为 19 4% (6 /31) ;S1和S4组比较 ,以及原发性肝癌组和S1、S2、S3或S4组比较存在统计学差异 (P <0 0 0 5— 0 0 1)。抗 HBe阳性率在S1、S2、S3和S4分期中分别为 11 1% (3/2 7)、2 1 2 % (7/33)、2 6 7% (8/30 )和 37 5 %(9/2 4) ,原发性肝癌组为 6 1 3% (19/31) ;S1和S4组比较 ,以及原发性肝癌组和S1、S2或S3组比较存在统计学差异(P <0 0 0 5— 0 0 5 )。结论 :这些结果提示 ,随着慢性乙型肝炎病程中逐渐出现从HBeAg至抗 HBe的自发血清转换 ,肝病的活动性没有降低 ,肝脏的纤维化程度逐渐加重 。
Purpose:In order to clarify the relations between the status of hepatitis B virus e system and fibrosis progress as well as carcinogenesis in the course of chronic hepatitis B.Methods:The positive rates of HBeAg or anti HBe were compared in different fibrosis staging of chronic hepatitis B as well as primary liver carcinoma.Results:The positive rates of HBeAg were 85.2% (23/27), 72.7%(24/33), 63.3%(19/30) and 50%(12/24) in the S1,S2,S3 and S4 fibrosis staging of chronic hepatitis B, along with 19.4%(6/31) in primary liver carcinoma. There were differences among the groups of S1 and S4, along with primary liver carcinoma and S1,S2,S3 or S4 ( P <0 005—0 01),respectively. The positive rates of anti HBe were 11.1%(3/27),21.2%(7/33),26.7%(8/30) and 37.5%(9/24) in S1,S2,S3 and S4 fibrosis staging of chronic hepatitis B, along with 61.3% (19/31) in primary liver carcinoma. There were differences among the groups S1 and S4, along with primary liver carcinoma and S1,S2 or S3 ( P <0 005—0 05), respectively.Conclusions:These results suggest that the activity of liver disease does not decline along with the spontaneous seroconversion from HBeAg to anti HBe in the course of chronic hepatitis B, in fact, the liver fibrosis is gradually aggravated; and the danger of carcinogenesis is increased.
出处
《中国癌症杂志》
CAS
CSCD
2000年第6期531-533,共3页
China Oncology
关键词
慢性乙型肝炎
E系统
肝纤维化
癌变
HBV
chronic hepatitis B
hepatitis B virus e system
liver fibrosis
carcinogenesis
