摘要
目的:观察直肠癌组织中胸苷磷酸化酶(TP)表达阳性情况,探讨其表达与临床病理参数之间的关系。方法:使用免疫组化方法检测直肠癌124例患者癌组织中TP表达:癌组织中染色细胞≥5%则为TP阳性。结果:直肠癌组织中TP阳性率为50%,TP表达与肿瘤浸润深度、解剖学分期有关联。结论:胸苷磷酸化酶在直肠癌组织及转移组织中明显高于正常组织,能诱导肿瘤组织中血管生长。TP表达阳性可能提示预后不良。
Objective: To evaluate Thymidine phosphorylase(TP) expression in rectal cancer tissues and find its relationship with clinicopathological parameters. Methods: Samples studied consisted of one hundred and twenty-four patients with rectal cancer. Immunohistochemical staining for TP was done and the tumor was considered positive when more than 5% of cells were stained. Results: The positive rate of TP expression in rectal carcinoma was fifty percent and TP expression was correlated with depth of invasion and stage. Conclusion: Thymidine phosphorylase has an angiogenic effect and is higher in rectal cancer tissues than in normal tissues beside the tumor. TP expression indicates a bad prognosis in rectal carcinoma.
关键词
直肠癌
胸苷磷酸化酶(TP)
免疫组化
临床病理特征
rectal carcinoma
thymidine phosphorylas(TP)
immunohistochemical staining
clinicopathological parameters
